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Volume 89 (1966)
- Issue 4 Pages 307-
- Issue 3 Pages 213-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 89, Issue 2
Displaying 1-8 of 8 articles from this issue
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Keishi Abe, Naoya Watanabe, Naofumi Kumagai, Toraichi Mouri, Toshikats ...1966 Volume 89 Issue 2 Pages 103-112
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA simple and accurate method for the determination of kinin in blood was described. It consists of the extraction of kinin with n-butanol at pH 2.0, elimination of sodium chloride from butanol phase, re-extraction of kinin into distilled water, concentration under reduced pressure, neutralization and assay on the isolated guinea-pig ileum against synthetic bradykinin as a standard. The recovery of added bradykinin was approximately 50 per cent. The method is also specific to kinin in blood and suitable for the clinical use. The kinin level estimated by this method was about 0-2 mμg per ml in normal persons.View full abstractDownload PDF (1650K) -
Kazuhiko Fukuda, Akira B. Miura1966 Volume 89 Issue 2 Pages 113-120
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDiagnostic value of vacuolated lymphocytes in the peripheral blood of juvenile amaurotic familial idiocy (AFI) was emphasized.
Vacuoles were never stained with Sudan III, Sudan black B and Nile blue cytochemically.
The abnormal corpuscles were observed by the electron microscope in the cells identified as lymphocytes. The vacuoles in Giemsa stained smears may correspond to these abnormal granules. Round bodies were the commonest, with an outer smooth limiting membrane, surrounding an inner vacant zone partly filled with electron-dense, amorphous or parallel double membrane-like materials. It was noteworthy that there was another kind of unique bodies which were composed of two or three concentrically arranged layers. The structure of these unusual bodies may be substantially the same as that of one of the membranous cytoplasmic bodies (MCB) found by Terry and Weiss.
In conclusion, it seems likely that the vacuoles within lymphocytes contain lipid. If it can be asserted that the MCB-like bodies are exactly the same as MCB, the relation-or lack of it-between vacuolated lymphocytes of juvenile AFI and the fundamental metabolic disturbance of the disease will be made clear.View full abstractDownload PDF (3478K) -
Hisao Aoba1966 Volume 89 Issue 2 Pages 121-130
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo assess the placental function, urinary excretion of estriol was estimated by the method developed by Kanbegawa. In normal pregnancy the mean urinary estriol always showed high values throughout the pregnancy, whereas in complicated pregnancy such as toxemia, retarded fetal growth and fetal death, it showed low values. Correlation between urinary value of estriol and feto-placental weight ratio was significant. The value of urinary estriol less than 10mg/day at term would imply placental dysfunction. Estimation of urinary estriol after administration of Diamox is much useful in the evaluation of the prognosis.View full abstractDownload PDF (1208K) -
Sadami Sato1966 Volume 89 Issue 2 Pages 131-142
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe biosynthesis of iodoamino acids in the nodule and paranodular thyroid tissue in nontoxic nodular goiter was studied in thirty patients by paperchromatography using Na-I131.
The following 4 characteristic findings of the nodule were obtained from this study: 1) The activity of iodination of MIT was reduced. 2) The storage of iodide resulting from deiodination was disturbed. 3) Biosynthesis of iodoamino acids in the nodule was influenced by pituitary-thyroid feed back mechanism in different way from that in the paranodular thyroid tissue. 4) Probably, there was a defect of deiodination.
It is an obscure problem whether these defects contribute in any way to the development of nontoxic nodular goiter or not, but our understanding of enzyme which activates iodination of MIT in the thyroid may provide a clue to the development of nontoxic nodular goiter.View full abstractDownload PDF (1313K) -
Minoru Inagaki, Tsuneo Yusa, Yuuko Aoba, Kenichi Iwatsuki1966 Volume 89 Issue 2 Pages 143-150
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFluoromar is a useful anesthetic agent except that it is flammable in the concentrations necessary for clinical anesthesia. According to Krantz et al., the azeotropic mixture of Fluoromar and Freon 113 possesses the advantage of reducing the flammability of Fluoromar and more useful in clinical practice. The purpose of the present investigation is to evaluate the anesthetic action, the lower limit of flammability and the circulatory effects of the azeotropic mixture, by comparing with those of Fluoromar.
The results showed that the lower limit of flammability of the azeotropic mixture was 7.1-7.4 vols. % in oxygen, apparently higher as compared with that of Fluoromar, which was 4.0-4.2 vols. % in the same condition, but the flammability of Fluoromar itself was not reduced significantly by Freon 113. Although Freon 113 exhibited a little synergistic effect upon the anesthetic action of Fluoromar, it appeared not enough to lower the concentration of Fluoromar in the azeotropic mixture below its flammable limit. Moreover, the cardiovascular depression was found far greater with the azeotropic mixture than with Fluoromar. So far as the results are concerned, the azeotropic mixture of Fluoromar and Freon 113 seems to have little advantage over Fluoromar as an anesthetic agent.View full abstractDownload PDF (335K) -
Tadasi Ohno, Minoru Hirooka1966 Volume 89 Issue 2 Pages 151-166
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThree males, 4 years, 6 years and 5 years of age, with typical Cockayne's syndrome were described.
Differential diagnostic criteria between Cockayne's syndrome and progeria were discussed and the authors were of the opinion that the two syndromes represented two different disease entities.
Histologic findings of the kidney biopsied in 2 cases with this syndrome revealed thickening of glomerular basement membrane and mesangium, collapse or atrophy of capillary loops, hyalinization of glomeruli, atrophy of tubules, thickening of the basement membrane of atrophic tubules and interstitial fibrosis. These renal lesions have not been reported so far in Cockayne's syndrome. In this respect, possible relationships between Cockayne's syndrome and so-called hereditary nephropathy were discussed.View full abstractDownload PDF (3666K) -
Yonosuke Watanabe1966 Volume 89 Issue 2 Pages 167-176
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe reticulo-endothelial system and fat cells of red bone marrow of the femur of guinea pigs, rats and rabbits was examined with the electron microscope.
1. The reticulo-endothelial tissue in the bone marrow consisted of reticulum cells and sinal endothelium.
2. The reticulum cells were characterized by large pale cytoplasm and a number of slender cytoplasmic processes which were thought to be connected with those of adjacent reticulum cells to form a cellular network. They also projected thin sheet-like processes toward the sinal walls and fat cells to cover their outer surface.
3. The sinal wall consisted of a single layer of endothelial cells. Only rudiments of basement membrane were present surrounding the sinal wall. The sinal endothelium showed gaps of various sizes, which were thought to be formed by the fenestration of the cytoplasm. Pseudopod-like processes of reticulum cells were seen to project into the sinal lumens through the endothelial gaps.
4. The fat cells contained single large fat droplets occupying the most part of the cytoplasm. In the perinuclear portion of the cytoplasm, a number of small droplets and glycogen granules were present. Basement membranes were seen surrounding fat cells.
5. After irradiation of 60Co, a marked proliferation of reticulum cells and fat cells were observed. The proliferated reticulum cells showed more abundant cytoplasmic organelles than normal ones and possessed numerous irregular cytoplasmic processes. On their surface were formed fibrous materials probably corresponding to reticulin fibers, which were not observed in normal cases.
6. As compared with endothelial cells of normal sinuses, those of irradiated cases showed thicker cytoplasm, prominent tight junctions and more complete basement membranes. Endothelial gaps were not observed in later stages of irradiation.View full abstractDownload PDF (3689K) -
Michio Hashimoto1966 Volume 89 Issue 2 Pages 177-191
Published: June 25, 1966
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe state or behavior of the reticuloendothelial cells of the bone marrow was investigated in rabbits and in human autopsy cases. The following results were obtained: 1) The behavior of the different constituent cells of the reticuloendothelial system in rabbits given foreign substances intravenously varied more or less according to substances injected. The cells or tissues playing a leading phagocytic role in rabbits were the sinusoidal endothelial cells when vitalstained with carmine; and mainly the sinusoidal endothelial cells, at first, and the reticulum cells, afterwards, in rabbits given intravenously foreign substances, such as India ink, Astrafer, Thorotrast and smut spores. 2) The bone marrow examined in autopsy cases indicated that, of all kinds of RES cells, those proliferating in response to a developing morbid condition are the reticulum cell and the free histiocyte, the sinusoidal endothelium remaining apparently un-increased in size or in number. 3) Red and fatty marrows were found affected to much different degrees in most cases with bone marrow lesions, and one of the reasons for this difference seems to be closely related to the functional difference existing between the RES of the red marrow and that of the fatty marrow.View full abstractDownload PDF (932K)
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