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Volume 101 (1970)
- Issue 4 Pages 299-
- Issue 3 Pages 205-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 101, Issue 3
Displaying 1-9 of 9 articles from this issue
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HIROSHI SAITO, TAKASHI FURUYAMA, RYUJI SHIOJI, SEIJU ONODERA, YASUHIKO ...1970 Volume 101 Issue 3 Pages 205-214
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPolyacrylamide gel electrophoretic and immunochemical studies were carried out on urine proteins in Sjogren's syndrome with definite renal tubular dysfunction. Proteinuria showed a distinctive tubular pattern, namely, a small albumin fraction less than 20%, of total urinary proteins, two or three distinct bands in a-region, and post y-protein. Proteinuria disappeared completely, when metabolic acidosis and hypokalemia were controlled by the administration of alkaline agents, and reappeared in parallel with recurrent metabolic acidosis and hypokalemia after the cessation of treatment, while renal tubular dysfunction persisted during treatment. The effect of metabolic acidosis and/or hypokalemia on defective renal tubular reabsorption of proteins is discussed. The values of relatve 1gG clearance were significantly increased in Sjogren's syndrome compared with those in chronic glomerulonephritis. It seems to suggest increased urinary excretion of low molecular weight protein antigenically related closely to serum lgG, and also to give another evidence of tubular proteinuria in Sjögren's syndrome.View full abstractDownload PDF (1480K) -
EIAKI TSUTSUMI, KAZUHIKO TAKANO, HIROSHI SUZUKI, C. T. HWANG, MAKOTO I ...1970 Volume 101 Issue 3 Pages 215-222
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new method was devised for the estimation of denatured plasma protein after long-term artificial perfusion. The method was based on the behavior of denatured protein, namely, decreased solubility and increased susceptibility to enzymatic hydrolysis. By this method, the extents of denaturation of plasma protein were compared after 20 hours perfusion using bubble, disc or membrane type oxygenators. Membrane type oxygenater was superior to non-membrane oxygenators in inducing less denaturation of plasma protein.View full abstractDownload PDF (371K) -
KEIYA TADA, TOSHIO YOSHIDA, TSUNEO ARAKAWA1970 Volume 101 Issue 3 Pages 223-226
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFree amino acid concentrations were determined in the liver biopsied or autopsied from the patients with amino acid disorder and from several controls. The results showed the accumulation of phenylalanine in phenylketonuria, of methionine and homocystine in homocystinuria, of cystathionine in cystathioninuria, of glycine in hyperglycinemia and of alanine in hyperalaninemia in the liver specimens biopsied from the patients with the respective disorders. Postmortem liver tissue from a patient with hyperglycinemia and a patient with homocystinuria also revealed an evident accumulation of glycine or homocystine. These findings suggest the significance of the postmortem diagnosis of inborn errors of amino acid metabolism.View full abstractDownload PDF (214K) -
MINORU HIROOKA, KUNI YOSHIOKA, TADASI OHNO, NAOKI KUBOTA, SEIJI IKEDA1970 Volume 101 Issue 3 Pages 227-235
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA male patient kat present, 8 years of age) with autoimmune hemolytic anemia of ‘warm type’ was under our observation since 3 years and 6 months of age, when he was first admitted to our hospital. The patient was treated by splenectomy and long-term steroid medication for 2 years and 3 months. However, because a complete remission could not be attained, the patient was thymectomized as a last resort at the age of 5 years and I month. Apparently, thymectomy was effective in reducing the steroid dosage (1.25mg 4 successive days a week to 0.75mg 3 successive days a week), in improving the clinical symptoms and in abolishing the necessities of blood transfusions.View full abstractDownload PDF (469K) -
TADAO SANJO1970 Volume 101 Issue 3 Pages 237-249
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSChemical, mineralogical and histochemical investigations of fatty acid-calcium stones were carried out in order to elucidate the mechanism of formation of gallstone components in general. The results obtained were as follows: 1) Systematic chemical analysis, infrared spectroscopy and gas chromatography of fatty acid-calcium gallstones obtained from 3 patients revealed that the predominant fatty acid in these stones was palmitic acid. Small amounts of stearic acid and oleic acid were also detected. 2) Fatty acidcalcium gallstones showed a laminated structure characterized by eccentrically arranged layers. Examinations under polarized light revealed fatty acid-calcium crystals between the layers of bile pigment particles which extended outwards in a fan-shape. 3) Histochemical examinations revealed the presence of diffuse networks of acid mucopolysaccharides containing sulfated radicals in fatty acid-calcium stones. Detailed examination of the net-works revealed a ubiquitous presence of acid mucopolysaccharides in the spaces between fatty acid-calcium crystals as well as in the layers, suggesting that these substances were playing an important role in holding crystals and particles together as bridges among other components of the stones. 4) On the basis of these findings it was concluded that severe infection of the biliary tract, release of fatty acid-calcium into the bile by enzymes and concrement formation of composite materials by acid mucopolysaccharide are essential in the formation of gallstones ofthis type.View full abstractDownload PDF (2619K) -
A. KULCSÁR, J. KULCSÁR-GERGELY, A. DARÓCZY1970 Volume 101 Issue 3 Pages 251-256
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSExperiments were performed with female rats to observe the correlations between thyroid function and liver damages. A method was elaborated based on the test of the total dye eliminating capacity of the rat liver. There were no essential changes in the elimination of BSP in animals with healthy liver in either hyperthyrosis or hypothyrosis. Subacute carbontetrachloride intoxication produced a slight change while chronic intoxication resulted in a severe change in the liver functions at carbontetrachloride dosages which in themselves hardly had any toxic effect. This was proven both by increased blood BSP levels and by histological findings. The total dye eliminating capacity of the liver was not impaired when carbontetrachloride treatment was performed in thyroidectomized rats. Hypothyroidism was found to have protective effect on the experimental liver lesion.View full abstractDownload PDF (283K) -
MITSURO NITTA1970 Volume 101 Issue 3 Pages 257-269
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe gustatory afferent impulses were recorded from the glossopharyngeal nerve after the application of chemical stimuli of four basic taste qualities to the toad tongue, and temporal patterns of the total number of impulses in a given time were obtained by a new summator, Nerve Impulse Count Summator. Statistical analysis of these temporal pattern of responses to chemical stimuli were made to assess whether one temporal pattern is similar to another or not. The results show that neither chemical specificity nor difference of taste substances given to the toad tongue affects the impulse pattern which appeared in the whole glossopharyngeal nerve.View full abstractDownload PDF (609K) -
MASAHIKO NOZAKI1970 Volume 101 Issue 3 Pages 271-279
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe pressure-volume relationship of a model alveolus was determined and the effects of cycling rate, bubble size and surfactant concentration on the pressure-volume relationship were studied. When the bubble was coated with the white layer isolated from lung wash of 22 dogs and pulsated between 650μ and 400μ in diameter at a rate of 12 cycles/minute, the maximal pressure was -32.0±4.2 mm H2O and minimal pressure was -2.2±1.4mm H2O. The pressure-volume curve showed a large hysteresis loop. The calculated surface tensions at 650μ and 400μ were 36.7±6.2 dynes/cm and 3.7±1.5 dynes/cm respectively. The pressure-volume relationship remained unchanged when the pulsation rate was varied from 6 to 180 cycles/minute. The results on the lung wash from three newborn lambs were similar to those obtained from the dogs, even though the white layer was diluted 50 times. With further dilution of the white layer, the pressure-volume relationship changed by bubble size and concentration of the white layer. As the bubble size decreased and/or the surfactant concentration increased, negative pressure at minimal bubble size decreased and the hysteresis loop increased. These findings indicated that a certain surface concentration of surfactant was necessary to achieve the surface activity and pulmonary hysteresis.View full abstractDownload PDF (541K) -
TETSUO SATO, HIROSHI ONOKI, ICHIKI KANO, TOGO HORIUCHI, TAKESHI ISHITO ...1970 Volume 101 Issue 3 Pages 281-288
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA fivemonth-old female with tricuspid atresia was successfully treated by Rashkind and Miller's balloon septostomy after banding of the pulmonary artery.View full abstractDownload PDF (3261K)
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