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Volume 139 (1983)
- Issue 4 Pages 331-
- Issue 3 Pages 225-
- Issue 2 Pages 113-
- Issue 1 Pages 1-
Volume 139, Issue 3
Displaying 1-15 of 15 articles from this issue
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YASUKO KOBAYASHI, HIROSHI SUZUKI, TASUKE KONNO, KEIYA TADA, TOSHI YUKI ...1983 Volume 139 Issue 3 Pages 225-230
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKOBAYASHI, Y., SUZUKI, H., KONNO, T., TADA, K. and YAMAMOTO, T.Y. Ultrastructural Alterations of Paneth Cells in Infants Associated with Gastrointestinal Symptoms. Tohoku J. exp. Med., 1983, 139 (3), 225-230 -Paneth cells containing abundant and large inclusion bodies found in patients with acrodermatitis enteropathica have been considered as a consistent and characteristic abnormality of this disease. We examined 34 children with gastrointestinal symptoms due to a wide variety of basic diseases and found similar abnormal Paneth cells in most of them, particularly in infants under the age of one year. This abnormality, according to our findings, is attributed to the secondary effect of zinc deficiency due to malnutrition.View full abstractDownload PDF (5083K) -
SHIGEMASA SAWADA, SHINGO IIJIMA, KEIJI KUWANA, SUSUMU NISHINARITA, JIN ...1983 Volume 139 Issue 3 Pages 231-238
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAWADA, S., IIJIMA, S., KUWANA, K., NISHINARITA, S., TAKEUCHI, J., SHIDA, M., KARASAKI, M. and AMAKI, I. Unusual Monoclonal DNA Binding Immunoglobulin. Tohoku J. exp. Med., 1983, 139 (3), 231-238 The monoclonal antibodies directed against DNA were produced by somatic cell hybridization with parental cells (SP-2) and spleen cells from nonimmunized autoimmune MRL/lpr mice. The immunoglobulins were recovered from the culture supernatant from hybridoma by a solid immunoadsorbent and antibody immunoprecipitation. The results from the specificities of DNA binding monoclonal immunoglobulins suggest that the antibodies to DNA have the antibody combining sites for both epitope of double stranded helicle and base of DNA and support the concept of the multiple antigen binding potentials of the hybridoma autoantibodies.View full abstractDownload PDF (770K) -
YOSHIFUSA AIZAWA, TAKAAKI CHOU, YOSHIMITSU YAZAWA, EIJI ODA, TOSHIYUKI ...1983 Volume 139 Issue 3 Pages 239-243
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAIZAWA, Y., CHOU, T., YAZAWA, Y., ODA, E., SHIBUYA, T., OZAWA, T. and SHIBATA A. Progression of Wenckebach Type A-V Block to High Degree A-V Block in Aged Man. Tohoku J. exp. Med., 1983, 139 (3), 239-243 This case report describes a 60 years old male with Wenckebach A-V block which progressed to high degree A-V block. Syncope and dizzy attacks were attributed to high degree A-V block in the study of ambulatory ECG (Holter). Wenckebach point was low; 90bpm when the right atrium was paced. At 140bpm, 2:1 A-H block with intermittent alternating and high degree A-H block were induced. Furthermore, a very wide His potential was recorded during the electrophysiological study. He received a permanent pacemaking. Since Wenckebach type A-V block is usually regarded as benign, this case seems to be rare.View full abstractDownload PDF (460K) -
TSUGUTAMI ONODERA, MITSUSHIGE NAKAMURA, TADAHIRO SATO, TOYOAKI AKINO1983 Volume 139 Issue 3 Pages 245-263
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSONODERA, T., NAKAMURA, M., SATO, T. and AKINO, T. Biochemical Characterization of Pulmonary Washings of Patients with Alveolar Proteinosis, Interstitial Pneumonitis and Alveolar Cell Carcinoma. Tohoku J. exp. Med., 1983, 139 (3), 245-263 -We have studied the biochemical compositions of fifteen pulmonary washings from seven patients with alveolar proteinosis, and two washings from two patients with interstitial pneumonitis and two from two patients with alveolar cell carcinoma. The pulmonary washing was separated into the supernatant and precipitate fractions by a brief centrifugation. Analytical results revealed that the pulmonary washings from patients with alveolar proteinosis contained much more protein and lipids as well as a higher percentage of phospholipid than did the pulmonary washings from other patients. With regards to alveolar proteinosis, the precipitate fraction, i.e., water-insoluble material, contained lipids as the major component, the majority of which was dipalmitoyl phosphatidylcholine. Protein in the sedimental material was small in amount, but was composed of proteins mainly of molecular weights of 62, 000, 36, 000, 28, 000 and 15, 000 as measured by SDS-gel electrophoresis. On the other hand, the supernatant fraction, i.e., water-soluble material, was composed predominantly of serum proteins, with the lipid content being lower than those in the precipitate fraction. These analytical findings support the idea that materials normally existing in the alveoli are excessively accumulated as alveolar-filling materials in alveolar proteinosis. It was also noted that there were marked differences in the lipid profiles between pulmonary washings from patients with alveolar proteinosis, and those from patients with other diseases, indicating that the biochemical composition of pulmonary washings tends to reflect the nature of an underlying disease. From these findings, the cause of the alveolar-filling materials found in alveolar proteinosis was discussed.View full abstractDownload PDF (2200K) -
HIDENARI TAKAHARA, YUKIO NAKAMURA, KAZUHIKO YAMAMOTO, HYOGO SINOHARA1983 Volume 139 Issue 3 Pages 265-270
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHARA, H., NAKAMURA, Y., YAMAMOTO, K. and SINOHARA, H. Comparative Studies on the Serum Levels of α-1-Antitrypsin and α-Macroglobulin in Several Mammals. Tohoku J. exp. Med., 1983, 139 (3), 265-270 -The sera of human, cattle, horse, sheep, goat, pig, dog, rabbit, guinea pig, rat, hamster, and mouse were assayed for total trypsin-inhibiting capacity, and for concentrations of α-1-antitrypsin and α-macroglobulin. The rodents examined showed striking species differences: the α-1-antitrypsin levels of mouse, rat, and guinea pig were more than twice the human level, while the α-macroglobulin levels of hamster and guinea pig were 340 and 40%, respectively, of the human level. On the other hand, little variations were found among the large domestic animals, their levels of the two inhibitors being similar to those of the human.View full abstractDownload PDF (489K) -
KATSUMI YOSHIDA, TOSHIRO SAKURADA, NOBUKO KAISE, KAZURO KAISE, MAKIKO ...1983 Volume 139 Issue 3 Pages 271-277
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYOSHIDA, K., SAKURADA, T., KAISE, N., KAISE, K., YAMAMOTO, M., SAITO, S. and YOSHINAGA, K. Thyroid Stimulation Test with Urinary T3 Concentration as an Index of Thyroid Response. Tohoku J. exp. Med., 1983, 139 (3), 271-277-Ten USP units of TSH (thytropar) were administered intramuscularly daily for three days to five euthyroid controls, to thirteen patients with chronic thyroiditis [four clinically euthyroid patients with normal serum TSH (Group I), five clinically euthyroid patients with elevated serum TSH (Group II) and four clinically hypothyroid patients with high serum TSH (Group III)], and to five patients with primary hypothyroidism Effects of TSH on the thyroid 24-hr uptake of 131I, 24-hr urinar T3 excretion and serum T3 concentration were assessed. In euthyriod controls, basal urinary T3 excretion was 0.76+0.26 (mean±S.D.) μg/day, increase to 1.31±0.16μg/day on the first day, to 2.33±0.75μg/day on the second day, and to a maximum of 2.78±0.65μg/day on the third day of TSH administration. In Group I, basal urinary T3 excretion was normal (0.58±0.16μg/day). Following TSH administration, the value increased to 1.60±0.62μg/day, but the rate of increase was less than that in euthyroid controls. In Group II, basal urinary T3 excretion was normal (0.71±0.37μg/day), but did not increase following TSH administration. In Group III, basal urinary T3 excretion was significantly low (0.32 ±0.07μg/day), and did not increase after TSH administration. In patients with primary hypothyroidism, basal urinary T3 excretion, 0.12±0.10μg/day, was lower than that of Group III, and did not increase after TSH administration. Positive correlations were found between urinary T3 excretion and serum T3 concentration before and after TSH administration. In contrast to basal serum T3 concentration and urinary T3 excretion, mean basal thyroid uptake of 131I in patients with chronic thyroiditis was higher than that of euthyroid controls. However, a positive correlation was found between the increased rate of urinary T3 excretion and the increase in thyroid 131I uptake after TSH administration. These observations indicate that the changes in urinary T3 excretion are reliable indices of the thyroid response to TSH administration in various states of thyroid functionView full abstractDownload PDF (702K) -
YOICHI IZUMI, MASANOBU HONDA, MICHINOBU HATANO, YUKINORI KAWAHARA1983 Volume 139 Issue 3 Pages 279-286
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIZUMI, Y., HONDA, M., HATANO, M. and KAWAHARA, Y. Influence of Food on the Clinical Effect of Angiotensin I Converting Enzyme Inhibitor (SQ 14, 225). Tohoku J. exp. Med., 1983, 139 (3), 279-286 -In order to clarify the influence of food on the clinical effect of angiotensin I converting enzyme inhibitor (SQ 14, 225, captopril), 25mg of the drug was administered to patients with hypertension using in a two-way crossover study design. In the first study (study I), each subject received the drug 30min after breakfast, and changes in blood pressure (BP), blood concentration of captopril (BCC), plasma renin activity (PRA), plasma aldosterone (PA) and plasma angiotensin I converting enzyme activity (ACE-A) were determined for 3 hr. BP was recorded for 6 hr. Four days after study I, the same subjects received the drug 2hr after breakfast, and each parameter was again determined (study II), similarly to study I. No significant difference in the hypotensive responses to captopril was observed between both studies during 6hr of observation. Maximum hypotensive effects were found within 90min of the treatments in study I and study II, and BP returned almost to baseline levels at 6 hr in both studies. Maximum BCC levels were found 60 and 90min after the drug administration in studies I and II, respectively, and these approximated to half of each maximum level at 180min. There were no statistically significant differences in the biological half-life (T1/2), maximum concentration (C max), maximum concentration time (T max), and area under the blood concentration curve [AUC]03 between both studies. The peak in PRA occurred at 60 and 90min after the administration of the drug in studies I and II, respectively. In study I, a slightly greater reduction of PA levels was found, but there was no significant difference in the magnitude of the reduction between both studies. The present results indicate that food did not exert any significant influence on the clinical effect of captopril.View full abstractDownload PDF (743K) -
CHIYUKI NAKANOME, HIROAKI AKAI, MASANORI UMEZU, TAKAYOSHI TOYOTA, YOSH ...1983 Volume 139 Issue 3 Pages 287-292
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKANOME, C., AKAI, H., UMEZU, M., TOYOTA, T. and GOTO, Y. Gastric Inhibitory Polypeptide (GIP) Response to an Oral Glucose Load in the Patients with Diabetes Mellitus. Tohoku J. exp. Med., 1983, 139 (3), 287-292 -Plasma gastric inhibitory polypeptide (GIP) concentrations following an oral glucose load were measured in 27 diabetics and 10 normal subjects. Plasma GIP concentrations increased significantly from the mean basal value following an oral glucose load in both groups. Diabetics showed significantly higher levels of plasma GIP in association with delayed and diminished peak increases in plasma insulin levels. When diabetics were divided into two groups according to their basal levels of blood glucose, moderate and severe diabetics exhibited more exaggerated increments of plasma GIP than mild diabetics. This exaggerated GIP response to an oral glucose load in proportion to the glucose intolerance indicates a relative failure of the beta cell response to GIP in diabetics and that the mechanism involved in hypersecretion of GIP would be diminution of the inhibition of GIP release caused by insulin in diabetics.View full abstractDownload PDF (474K) -
TATSUMI UCHIDA, TADAYUKI IGARASHI, TERUO SUZUKI, KEIJI KOKUBUN, SHIN M ...1983 Volume 139 Issue 3 Pages 293-298
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSUCHIDA, T., IGARASHI, T., SUZUKI, T., KOKUBUN, K., MATSUDA, S. and KARIYONE, S. The Effect of Acute Inflammation on Iron Metabolism in Rats. Tohoku J. exp. Med., 1983, 139 (3), 293-298-Iron metabolism in rats with acute turpentine-induced inflammation was evaluated. In acute inflammation, reduced plasma iron and total iron-binding capacity values, shortened plasma iron disappearance time and lower plasma iron turnover were observed. The administration of 59Fe chondroitin ferrous sulfate in order to evaluate the reticuloendothelial (RE) function revealed a significantly increased 59Fe retention in the liver and lower incorporation into red blood cells. Radioactivity in hepatic RE cells was higher in acute inflammation than in control. These results suggest the possibility of a block in the transfer of iron from RE cells to the plasma iron pool during acute inflammation.View full abstractDownload PDF (578K) -
KAZUHIKO FUKUDA, TOSHIKUNI ETOH, TOSHIHARU IWADATE, ATSUSHI ISHII1983 Volume 139 Issue 3 Pages 299-307
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUKUDA, K., ETON, T., IWADATE, T. and ISHII, A. The Course and Prognosis of Manic-Depressive Psychosis: A Quantitative Analysis of Episodes and Intervals. Tohoku J. exp. Med., 1983, 139 (3), 299-307-A quantitative analysis of episodes and symptom-free intervals in the course of manic-depressive psychosis was attempted. 1, 066 patients who visited Tohoku University Hospital between 1955 and 1965 were investigated by a mail questionnaire and subsequent review of records in their care hospitals. There was no difference between the reply group and non-reply group in terms of demographic status. About 6.2% of patients were chronically ill. Eighteen percent of patients were dead at the time of study. The number of episodes was about three in depression and about seven in bipolar type during twelve years of observation. The length of symptom-free interval between episodes was about five years in depression and two years in bipolar type. There was no difference in the number of episodes or in the length of interval between 1955-1959 group and 1960-1965 group. The change of length was not confirmed between early and late intervals.View full abstractDownload PDF (837K) -
NOBUHIKO SAJIKI, NORIO MORIAI, RYUICHI NAKAMURA1983 Volume 139 Issue 3 Pages 309-314
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAJIKI, N., MORIAI, N. and NAKAMURA, R. Effect of Passive Movements on Reaction Time of the Rectus Femoris in Normal Subjects and Patients with Paraparesis. Tohoku J. exp. Med., 1983, 139 (3), 309-314 -Electromyographic reaction times (EMG-RTs) of the right knee extension were examined in eight normal subjects and eight patients with paraparesis under three conditions; during passive knee flexion (PFLX), passive extension (PEXT) and no passive movements (STAT). EMG-RTs of the three conditions were not significantly different between the normal and the patient group. A two-way analysis of variance (condition×group) showed that the main effect of condition was significant, but that of group and the interaction were not. Both in the normal and the patient group the shortest EMG-RTs of all was obtained in PEXT, followed by that of STAT and PFLX. Effect of passive movements on EMG-RTs in the patients whose position sense of the knee and muscle strength of the knee extension were within normal range did not vary with the abnormality of tactile sense and/or myotatic reflexes. The results indicated that activities of the pyramidal tract neurons in carrying out a movement were directy influenced by kinesthetic information of the moving limb.View full abstractDownload PDF (534K) -
RYOSUKE NEMOTO, MASAAKI SHINDO, HISASHI MORI, RYOETSU ABE, TETSURO KAT ...1983 Volume 139 Issue 3 Pages 315-320
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNEMOTO, R., SHINDO, M., MORI, H., ABE, R. and KATO, T. Intravesical Chemotherapy of Urinary Bladder Tumor in Rabbit by Ferromagnetic Mitomycin C. Tohoku J. exp. Med., 1983, 139 (3), 315-320 -Considering the necessity of selective toxicity in cancer chemotherapy, an advantageous means of controlling the anticancer agent in the urinary bladder was facilitated by microencapsulation of the drug and ferrite particles. Pharmacokinetic analysis of intravesical instillation chemotherapy in rabbits proved that magnetic control of ferromagnetic microencapsulated mitomycin C (MMC) remarkably enhanced MMC absorption into the urinary bladder wall. Moreover, malignant bladder tumors in rabbits were successfully treated with this method.View full abstractDownload PDF (502K) -
RYOJI MINAMI, TOMOYASU IKENO, CHIHARU IGARASHI, SATOSHI TSUGAWA, TOORU ...1983 Volume 139 Issue 3 Pages 321-326
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMINAMI, R., IKENO, T., IGARASHI, C., TSUGAWA, S. and NAKAO, T. Characterization of Keratan Sulfate Isolated from Liver Affected by Morquio Syndrome. Tohoku J. exp. Med., 1983, 139 (3), 321-326 Chemical structures of keratan sulfate (KS) isolated from the liver affected by Morquio syndrome type A (classical type) were investigated. In the KS from Morquio syndrome liver, the molar ratios of hexose, total sulfate, N-sulfate and sialic acid to hexosamine were 5.07, 0.90, 0.18 and 0.08, respectively, and about 10% of hexosamine consisted of galactosamine. The KS resulted in a production of oligosaccharides of relatively larger size after digestion with keratanase, as compared with bovine corneal KS. These findings strongly suggest that KS accumulated in the liver affected by Morquio syndrome may be derived from bony KS.View full abstractDownload PDF (700K) -
KENICHI WATANABE, YOICHI HIROKAWA, EIJI OHTAKI, TSUNEO NAGAI, AKIRA SH ...1983 Volume 139 Issue 3 Pages 327-328
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, K., HIROKAWA, Y., OHTAKI, E., NAGAI, T., SHIBATA, A. and EGUCHI, S. Usefulness of Two-Dimensional Echocardiography for Diagnosis of the Sites of Origin in Myxoma. Tohoku J. exp. Med., 1983, 139 (3), 327-328-Three patients with atrial myxoma, two in the left atrium and one in the right were studied using two-dimensional echocardiography. An analysis by four cross sections, long and short axis, subcostal and four chamber views of the left ventricle showed that the stalk of one left atrial myxoma adhered to the anterior commissure, the other to the left atrial wall underlying on the aortic posterior wall, and that of right myxoma to the free wall of the right atrium. The myxomas were successfully removed by surgical intervention in all cases, where the sites of stalk were verified to be identical with those diagnosed by echocardiography.View full abstractDownload PDF (332K) -
SEIGI TSUCHIDA, TAKASHI MORITA1983 Volume 139 Issue 3 Pages 329-330
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTSUCHIDA, S. and MORITA, T. Discrepancy between the Renal Pelvic Fluctuations and the Pacemaker Discharges at the Pelvi-calyceal Border. Tohoku J. exp. Med., 1983, 139 (3), 329-330 -Experiments were performed in vitro to explore the influence of isoproterenol on the canine pelvi-ureteral system. The rhythmic changes of intrapelvic pressure became no longer manifest and simultaneously recorded electromyograms revealed disappearance of peristalsis at sites distal to the upper region of renal pelvis following application of isoproterenol, while the pacemaker at the pelvi-calyceal border continued to discharge with an enhanced pace. This result has demonstrated that the renal pelvic pressure recorded during treatment with isoproterenol did not reflect the pacemaker activity of the renal pelvis.View full abstractDownload PDF (187K)
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