All issues
Volume 95 (1968)
- Issue 4 Pages 317-
- Issue 3 Pages 203-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 95, Issue 2
Displaying 1-12 of 12 articles from this issue
- |<
- <
- 1
- >
- >|
-
Keiya Tada, Yoshimasa Yokoyama, Hiroshi Nakagawa, Tsuneo Arakawa1968 Volume 95 Issue 2 Pages 107-114
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAnother family of B6 dependent xanthurenic aciduria is reported. The results of in vivo and in vitro studies of the patients agreed with those from our previous patients of the first family.1
The view, mentioned previously, 1 that the basic defect of the disorder is the inability of an apoenzyme (kynureninase) to combine normally with the coenzyme (pyridoxal phosphate) was confirmed.
Causal relationship between mental retardation and biochemical disturbance is discussed.View full abstractDownload PDF (416K) -
Tsunenobu Tamura1968 Volume 95 Issue 2 Pages 115-120
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrinary excretion of formiminoglutamic acid following an oral dose of histidine was decreased in children with riboflavin deficiency than in those without it.View full abstractDownload PDF (277K) -
Naofumi Kumagai, Keishi Abe, Toraichi Mouri, Toshikatsu Seki, Kaoru Yo ...1968 Volume 95 Issue 2 Pages 121-126
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSP-tosyl-l-arginine methyl ester hydrochloride (TAMe) esterase activity in human plasma was estimated on 30 healthy subjects and 130 patients with various diseases. In healthy subjects, TAMe esterase activities were 9-34μM/ml/hr with the mean value of 17. 8μM/ml/hr. Markedly low activities were observed in patients with carcinoma of the lung. In 9 out of 12 patients with carcinoma of the stom-ach, TAMe esterase activities were low.View full abstractDownload PDF (323K) -
Atsuo Suzuki, Akira Shibata, Seiju Onodera, Akira B. Miura, Shinobu Sa ...1968 Volume 95 Issue 2 Pages 127-134
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA double staining method was devised for simultaneous histochemical demonstration of acid and alkaline phosphatase activities on the same bone marrow smears. The fixation was done by neutral formaldehyde vapor for 5 minutes at room temperature. The incubation for demonstration of acid phosphatase was firstly carried out by immersing the smears in a medium containing naphthol-ASBI-phosphate as the substrate and Fast red violet LB salt as the coupler at 37°C for 2 hours. Next, the smears were incubated in a medium for alkaline phos-phatase using naphthol-ASMX-phosphate as the substrate and Fast blue RR as the coupler at 37°C for 3 hours.
Interesting results were obtained concerning the cells of neutrophilic series and the reticuloendothelial cells. Immature neutrophils disclosed red staining indicating acid phosphatase activity and gradually lost red color with increasing blue staining due to increasing alkaline phosphatase activity along with cell maturation. Reticuloendothelial cells showed intense acid and alkaline phos-phatase activity, and they could be classified into four groups according to the behavior to the enzyme staining: 1) The group of cells possessing only acid phosphatase activity. 2) The group of cells showing more intense reaction to acid phosphatase than to alkaline phosphatase. 3) The group of cells showing more intense reaction to alkaline phosphatase than to acid phosphatase. 4) The group of cells having only alkaline phosphatase activity. The average rate of appearance was 49% for the 1st group, 3% for the 2nd group, 40% for the 3rd group and 8% for the 4th group. Reticuloendothelial cells belonging to the 1st group were found increased in the bone marrow of the patients with malignant reticulosis.View full abstractDownload PDF (505K) -
Takashi Nakarnura, Takashi Kutsuzawa, Satoru Takahashi, Sohsuke Takaha ...1968 Volume 95 Issue 2 Pages 135-144
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe cerebral hemodynamics was studied in 5 patients with cerebral arteriovenous aneurysms using the nitrous oxide method and the dye-dilution method, and special reference was made to shunted blood flow. Cerebral blood flow measured by the nitrous oxide method tended to increase generally, while cerebral vascular resistance decreased. Dye-dilution curve from the internal jugular bulb following the injection into the carotid artery was characterized by the shortness of the appearance time and abnormal hump on the build-up slope. It was assumed that the first part of the curve represented shunted flow and the second wave normal cerebral blood flow. The proportion of dye passing through the shunt was obtained by the ratio of the area of shunt curve to the summed areas cf both curves on semilogarithmic paper. The shunt calculated from single dilution curve varied significantly according to experimental conditions of dye injection into the right or left carotid artery and dye recording from the right or left jugular bulb. The per cent values of the shunt in 4 cases estimated by averaging the right and left shunt ratios of the brain were 72, 53. 8, 33. 5 and 17. 6%. There existed a rough correlation between the shunt ratio of the brain and cerebral blood flow measured by the nitrous oxide method. In 2 cases, in which the tumors were surgically extirpated, pre-and postoperative studies were made.View full abstractDownload PDF (1259K) -
Seiju Onodera, Akira Shibata, Akira B. Miura, Atsuo Suzuki, Shinobu Sa ...1968 Volume 95 Issue 2 Pages 145-151
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSerum immunoglobulin D (IgD) level was determined in 10 normal subjects, 5 cases of IgD-myeloma and 23 cases of various autoimmune diseases by the antibody-agar plate method using the antiserum against the heavy chain of IgD, which had been prepared in a rabbit immunized with an IgD-myeloma protein.
The serum IgD level was below 0.05mg/ml in normal subjects and above 10mg/ml in IgD-myeloma cases. In one case, IgD levels were serially followed; the level dropped to 1.0mg/ml by administration of cyclophosphamide. More than a half of cases of various autoimmune diseases showed the serum IgD levels of above 0.05mg/ml. The highest level in this autoimmune disease group was 0.14mg/ml in a case of aortitis. All of the 4 cases of aortitis studied showed IgD levels of above 0.05mg/ml. Whether serum IgD elevation in autoimmune diseases is an expression of general elevation of immunoglobulins or represents the elevation of antibodies specific for these diseases awaits further studies.View full abstractDownload PDF (1530K) -
Hiroyuki Ikeda1968 Volume 95 Issue 2 Pages 153-168
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSExperiments were done in dogs anesthetized with Nembutal. Adrenal venous blood was collected and analyzed for adrenaline and noradrenaline by the fluori-method. In intact dogs insulin hypoglycemia was accompanied by a marked metric increase in adrenal medullary secretion. In dogs whose spinal cord was transected at the level of the lowest cervical segment one or 4-7 days previously, the adrenal medullary secretion was increased significantly by insulin hypogly-cemia. The magnitude of increase in these dogs was, however, far smaller than that in intact ones. Section of the splanchnic nerves abolished almost com-pletely the rise in adrenal medullary secretion of the ipsilateral gland in response to insulin hypoglycemia. It is concluded that although the thoracic (or thoracico-lumbar) spinal center is sensitive to hypoglycemia and plays some role in promoting adrenal medullary secretion, the upper center situated above the level of spinal cord transection plays a more essential role for the adrenal medullary response to hypoglycemia.View full abstractDownload PDF (854K) -
Kazuhiko Inoue, Eiji Takahashi, Toshiaki Adachi, Ryohei Oikawa, Takesh ...1968 Volume 95 Issue 2 Pages 169-176
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrinary excretion of norepinephrine (NE), epinephrine (E), normetanephrine (NMN), metanephrine (MN) and vanillyl mandelic acid (VMA) were measured in 10 hypertensive and 10 normotensive subjects at walking and in sleep. No difference in urinary excretion of each of NE, E, NMN, MN and VMA was observed in sleep between the hypertensive and normotensive subjects. Urinary excretions of NE, E, NMN, MN and VMA at walking were 3 to 6 times higher than those in sleep in both groups. The rate of increase in catecholamine excretion at walking was higher in the hypertensive subjects. At walking, urinary excretion of VMA in the hypertensive group was significantly higher. The ratio of VMA to total catecholamine was lower at walking.
Elevated urinary catecholamine excretion in the hypertensive suggests that the substance plays a role as a causative factor of hypertension.View full abstractDownload PDF (442K) -
Rikuro Sasaki, Yasuo Watanabe, Toshiaki Morishita, Shoichi Yamagata1968 Volume 95 Issue 2 Pages 177-184
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe total number of heart muscle cells of rats was estimated by a histometrical method. It was approximately 5 millions immediately after birth and rapidly increased to over 19 millions in the first month of life. Then it gradually increased to 20-22 millions by the age of 2 years. The total number of interstitial cells was approximately 3.5 millions immediately after birth, and increased progres-sively to 28 millions in a month, to 68 millions in a year and to 72 millions in 2 years. The number of heart muscle cells per 1mm3 of heart muscle was approximately 330, 000 immediately after birth and decreased with growth to about 1/9 of the initial number in 2 years. It was concluded that the heart muscle cells as well as the interstitial cells increased by cell division even after birth, and that the heart muscle cells not only increased in number, but also grew in size during the normal growth of the organ.View full abstractDownload PDF (381K) -
Rikuro Sasaki, Yasuo Watanabe, Toshiaki Morishita, Shoichi Yamagata1968 Volume 95 Issue 2 Pages 185-192
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTotal DNA content of the whole heart muscle of rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined according to the microspectrophotometric method, in order to obtain further evidence supporting the view of cell division of the heart muscle. Total DNA content of the whole heart muscle was lowest immediately after birth and increased lineally with growth and amounted up to approximately 10 times in 2 years. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant throughout cardiac growth. These results seem to substantiate our view that heart muscle cells as well as interstitial cells divide and increase in number with the growth of the heart after birth.View full abstractDownload PDF (468K) -
Hiroki Watanabe1968 Volume 95 Issue 2 Pages 193-199
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe sacral nerves or the hypogastric nerve were divided in 23 adult male dogs, and QO2, QCO2 and the activities of succinic dehydrogenase (SDH) and latic de-hydrogenase (LDH) of the prostatic tissue were measured on the 7th and 21st postoperative days. The results were summarized as follows:
1) QO2, QCO2 and R. Q. usually decreased after the interruption of prostatic innervation.
2) Both SDH and LDH activities usually increased, while the SDH/LDH ratio was always reduced because the increase in LDH activity was larger than that of SDH.
3) These changes were also observed after division of the hypogastric as well as the sacral nerves.
4) The changes persisted for a considerably long period.View full abstractDownload PDF (319K) -
Akinori Nishiyama1968 Volume 95 Issue 2 Pages 201-202
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (621K)
- |<
- <
- 1
- >
- >|