The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 20, Issue 5-6
Displaying 1-15 of 15 articles from this issue
  • 38th Report. Uranyl Nephritis in Individuals with Different Liver Power of Detoxication. An Evidence of Close Relation between the Liver and the Kidney
    TATSUO SATO
    1933 Volume 20 Issue 5-6 Pages 399-407
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Starting from the fact that the lethal dosis of uranyl salt is very different according to different authors and that a certain relation is seen from a study of the literature between the liver and the kidney; I selected b- and f-classed rabbits according to the ammonia-detoxi-cating liver power (Cf. Sato-Sakurada's liver function test8)) and performed the experiment of uranyl nephritis. A subcutaneous injection of 0.1% uranyl acetate was made in an amount of 1.5 c. c. per kilo of body weight. The b-classed animals (of low-classed ammonia-de-toxicating liver power) succumbed without an exception, while, most of the f-classed rabbits (of high-classed liver power) outlived the poisoning excellently. This wide difference of susceptibility between both kinds of animals was also seen in the figures of blood urea. The same renal poison in the same amount reacted in a thus almost essentially different manner in rabbits of different liver power, _??_a very clear evidence of the close relation between the liver and the kidney.
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  • 39th Report. Effect of Yakriton upon Uranyl Nephritis
    TATSUO SATO
    1933 Volume 20 Issue 5-6 Pages 408-419
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • 40th Report. Prophylactic Effect of Yakriton† against Toluylendiamine-jaundice
    MATSUITI YOSHIDA
    1933 Volume 20 Issue 5-6 Pages 420-428
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Since the publication of yakriton, the efficacy of the hormone has been reported by different authors outside of this laboratory. On the base of these clinical reports I have made a plan of experimental work concerning toluylendiamine-jaundice and yakriton, from which the following results have been obtained.
    1. Toluylendiamine-jaundice is produced in normal dogs, if 2 or 2.5% solution of the diamine is subcutaneously injected in the amount of 1 c. c. per kilo of body weight.
    2. Yakriton will act to mitigate the jaundice in its 1/2 R. A. U. (Rabbit-Ammonia-Unit). When it is used in the amount of 2 R. A. U. per kilo almost no bilirubinemia will occur.
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  • 42nd Report of the Peroxidase Reaction
    KYUMATSU ASAKURA, HUJIO OHSAKO
    1933 Volume 20 Issue 5-6 Pages 429-433
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Sadao Miyachi
    1933 Volume 20 Issue 5-6 Pages 434-451
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • III. Mitteilung: Zur Frage der Zucker- oder Azetonkörperbildung aus infundiertem Fett
    Toji Baba
    1933 Volume 20 Issue 5-6 Pages 452-470
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    1. Nach intravenöser Infusion hoch dispergierter Fettemulsion in einer Menge, die deutliche R. -Q. -Senkung gegenüber der Norm hervorrufen kann, lässt sich bei pankreasdiabetischen Hunden weder Steigerung des Blutzuckers noch Mehrausscheidung von Zucker in den Harn nachweisen.
    2. Man findet aber dabei beträchtliche Vermehrung von Azetonkörpern im Harn und, wenn auch nicht so ausgesprochen, ebenfalls im Blute. Daraus wurde geschlossen, dass die R. -Q. -Senkung nach Fettinfusion durch Ausscheidung der aus infundiertem Fett gebildeten Azetonkörper bedingt ist.
    3. Hyperglykämie nach Gabe von Azetonkörpern wurde bestätigt, dagegen Zuckerbildung aus diesen abgelehnt.
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  • TOSIMITU KAIWA
    1933 Volume 20 Issue 5-6 Pages 471-497
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In the dogs bilaterally splanchnicotomized, without or with removal of the sympathetic ganglia in the abdominal cavity, peptone alone, adrenaline infusion alone and both drugs together were injected into veins. Adrenaline hydrochloride was in fact intravenously administered just with the velocity with which epinephrine is liberated from the suprarenals when such a dose of peptone is applied. The velocity of epinephrine liberation on poisoning with peptone of 0.1 to 0.3 grm. per kilo, utilized as the pattern in the present investigations, was the mean calculated from five dogs of Watanabe, which showed rather common outcome, that is a moderate acceleration in the epinephrine discharge on receiving the above mentioned dosage.
    The hyperglycaemia with adrenaline, given in the amount and manner above mentioned, was clearly smaller than that induced by peptone alone in such a dose or by peptone with adrenaline. Peptone alone, in doses applied, induced hyperglycaemia of a large magnitude, and when both drugs were injected in combination the hyperglycaemia was either wholly similar or definitely smallar than that obtained by peptone alone. Summation of glycaemic effect of both drugs was seen only exceptionally.
    It may be thus concluded that epinephrine liberation occurring in the peptone intoxication has not only no share in the production of the hyperglycaemia appearing there but on the contraty rather acts sometimes to reduce it.
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  • FUMIO OHMI
    1933 Volume 20 Issue 5-6 Pages 498-507
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Being led by two recent papers noting non-glycaemic action of the sensory stimulation in the cats when the suprarenal glands were excluded anatomically or from functioning, we have attacked this kind of experimentation again, that is sensory stimulation was tried on rabbits, normal, and long surviving either double splanchnicotomy or doubly suprarenalectomy. The cephalad cut end of the sciatic nerve was used for the sensory stimulation. The results are as follows: While the double splanchnicotomy diminishes on a large scale the magnitude of the hyperglycaemia due to sensory stimulation, the removal of the suprarenal glands does so only to a quite small extent or almost nothing.
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  • FUMIO OHMI
    1933 Volume 20 Issue 5-6 Pages 508-516
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Contrary to a previous writer we have not been able to find a definite relationship between the intraocular tension and the suprarenal glands in his sence; otherwise expressed, the intraocular pressure did not undergo any diminution by removing the suprarenal glands in rabbits or the suprarenal medulla in a cat. These animals survived well the operation, a common matter.
    It may be further added: In some cats the suprarenal glands were removed, without further special treatment. The intraocular tension was found to diminish gradually, and in fact in parallel with the development of general weakness.
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  • Tasuku Inawashiro
    1933 Volume 20 Issue 5-6 Pages 517-543
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Obige Untersuchungsergebnisse seien im folgenden zusammenfassend angeführt.
    1. Wenn man einem gesunden kaninchen von 20% iger Traubenzuckerlösung 8 ccm pro kg im Geschwindigkeitsverhältnis von 10 ccm in der Minute intravenös injiziert, so erhöht sich die Blutzuckerkurve, welche aber in 3 Stunden danach auf den früheren Wert wieder herabsinkt.
    2. Das Blut sowohl des Kaninchens mit beiderseits exstirpierten Nieren wie auch des Kaninchens mit unterbundenden Ureteren weist einen hyperglykämischen Zustand auf gegenüber demselben eines gesunden Kaninchen, und bei oben genannten beiden Tieren ist die Erniedrigung der nach Traubenzuckerzufuhr gesteigerten Blutzuckerkurve sehr verzögert. Dies ist bei Kaninchen mit unterbundenen Ureteren mehr auffallend. Dieses Phänomen kann bei Kaninchen mit der mit Kantharidin bzw. Uran beschädigten Nierenfunktion ebenfalls konstatiert werden und diese Abweichung tritt bei Urankaninchen mehr ausgesprochen zutage.
    3. Der Blutzuckerwert eines thyreoidektomierten Kaninchens ist etwas niedriger als derselbe eines gesunden Kaninchens, während der Blutzucker eines Kaninchens mit dem durch fortgesetzte Darreichung des Schilddrüsenpräparates herbeigeführten Hyperthyreoidismus sich gewissermassen höher als derselbe eines gesunden Kaninchens erweist. Die Erniedrigung der durch die Traubenzuckerinjektion gesteigerten Blutzuckerkurve verzögert sich beim ersten mehr als beim letzten und bei diesen beiden Fällen protrahiert sie gemeinschaftlich in erheblichem Masse im Vergleich mit derselben beim gesunden Kaninchen.
    4. Der Blutzuckerwert eines Kaninchens mit dem blockierten reticuloendothelialen Apparat erhöht sich proportional mit der Intensität der Blockade und die Erniedrigung der nach Traubenzuckerzufuhr gesteigerten Blutzuckerkurve verzögert sich ebenfalls proportional mit ihr.
    5. Der Blutzuckerspiegel eines B-avitaminösen Kaninchens ist höher als bei der Norm; die nach Traubenzuckerinjektion erfolgende Erhöhung des Blutzuckerspiegels ist zwar keineswegs erheblicher gegenüber derselben eines normalen Kaninchens, die Zeitdauer aber, in welcher der erhöhte Blutzucker bis auf den normalen Wert herabsinkt, zieht ausserordentlich in die Länge.
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  • Tasuku Inawashiro
    1933 Volume 20 Issue 5-6 Pages 544-552
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Tasuku Inawashiro
    1933 Volume 20 Issue 5-6 Pages 553-582
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Enaji Hayasaka, Tasuku Inawashiro
    1933 Volume 20 Issue 5-6 Pages 583-590
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Takashi Toyoma
    1933 Volume 20 Issue 5-6 Pages 591-595
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Takashi Toyoma
    1933 Volume 20 Issue 5-6 Pages 596-599
    Published: March 20, 1933
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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