In Japan, reports on tumors in the cutis of dogs are few. The author herein presents clinical and histopathological findings on a dog with multiple tumors in all parts of the skin.
Case: A male Shepherd dog 7 years of age.
1. Macroscopic Findings. Tumors were found in more than 50 sites in all parts of the skin and were between 0.1 and 1. 5cm in diameter. When palpated, they were moderately hard tumors which were buried beneath the cutis. Some of them projected on the cutis as cabbage-like lumps of lipoid or keratoid substance. No pain nor reddening was observed at the sites of the tumors.
2. Histological findings. The tumors consisted of aggregated epithelial cells, allowing the assumption that they were pressed through the cutis into the corium, where they proliferated. They were arranged spherically at many sites, with a strongly cornified area in the center.
All the tumors were of nearly uniform shape, including few atypical ones, and were always partitioned off from heut srrounding tissuses by a connective-tissue capsule. There was no infiltrative, destructive proliferation of humor cells into the surrounding tissues; this is un usual with the cells of malignant tumors. The tumors found in the eyelids showed no findings differing from those in the other sites.
The findings above are identical with those of the case of epithelioma adenoides cysticum, so called by Brooke, of the human skin.
3. Treatment. The tumors were excised one by one. They show recurrence, but the dog, is still alive.
4. Explanation of figures. Fig. 1. Macroscopic picture of an excised tumor. Left: surface. Middle: cut surface. Right: protrusion of tumor content on the skin surface.
Fig. 2. Histological picture of the cut surface of a tumor formed on the body trunk in a comparatively early stage. Upside: skin surface.(HE stain, under magnifying glass.)
Fig. 3. Tumor in the eyelid.(H-E-stain, under magnifying glass.)
Fig. 4. Histological picture showing a tumor originated from a hair follicle. A mass of keratic substance is found at the root of the hair follicle.(H-E stain, under magnifying glass.)
Fig. 5. Histological picture showing a tumor originated from a hair follicle. Similar cells containing pigment granules are found in the tumor as well as in the hair follicle.(H-E stain; under moderate magnification.)
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