巻号一覧
48 巻 (1952)
- 5 号 p. 273-
- 4 号 p. 159-
- 3 号 p. a151-
- 2 号 p. 91-
- 1 号 p. 1-
前身誌
48 巻, 1 号
選択された号の論文の10件中1～10を表示しています
- |<
- <
- 1
- >
- >|
-
Aminosulfon-酸の血管作用に就て土田 和夫1952 年 48 巻 1 号 p. 1-15,en1
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーActions of aminosulfonic acids (taurine, 1-amino-2-oxypropane-sulfonic acid, 1-methylamino-2-oxypropane-sulfonicacid, benzoylamino-oxypropane-sulfonicacid, betaine of sulfonic acid, betaine of 1-pyridyl-2-oxypropane-sulfonic acid, and sulfanilic acid) were examined on the blood-vessel of a frog's hind leg in comparison with that of aminocarbonic acids and of their derivatives (glycocoll, l-leucine, dl-leucine, l-tyrosine, histidine, arginine, isoserine, glycyl-glycine, glycine anhydride, hippuric acid, phenylhippuric acid, ornithuric acid, a-pyridinuric acid, and a-pyridinornithuric acid) and other chemically related compounds (creatine, creatinine, p-aminobenzoic acid, and diphenyloxyethylamine hydrochloride). Result : Aminosulfonic acids exerted generally weak dilatations on blood-vessels and contractions were seen only in the strong solutions. Aminocarbonic acids acted similarly very weakly, among which glycocoll, diglycine, arginine, etc. showed primarily dilation and then contraction. In the experiment on the epinephrine combination taurine, aminoxypropane-sulfonic acid and its methyl and benzoyl derivatives, betaine of sulfonic acid, betaine of pyridyloxypropane-sulfonic acid, etc. inhibited the epinephrine action on blood-vessels.抄録全体を表示PDF形式でダウンロード (2579K) -
(附) 鎭痛作用久本 一與1952 年 48 巻 1 号 p. 16-24,en1
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーHetrazan increases the tone as well as the motility of longitudinal and circular muscles of the isolated small intestine of rabbits in a lower concentration, while in a higher concentration the stimulation is followed by depression. These effects are remained, uninfluenced by atropine and ergotamine, and the actions of acetylcholine and pilocarpine are not affected by hetrazan, but nicotine and MgCl2 antagonize completely the stimulant action of hetrazan, where the dose of MgCl2 does not affect the action of acetylcholine. On the intestine depressed by hetrazan both of these drugs have no effects. Similar effects of hetrazan are also observed in situ where the drugs are applied intravenously and where in other cases they are applied to the mucous or serous membrane. Although. the sectioning of the vagus, the splanchnic nerve and the thoracic cord, and. also the application of atropine cause a scarce effect on the stimulant action of hetrazan, while by the intravenous introduction of nicotine the action of hetrazan is completely suppressed. On the isolated non-pregnant uterus of a rabbit, hetrazan increases its motility which is to be checked by MgCl2, nicotine and a large dose of hetrazan. From these facts it may be concluded that hetrazan acts on the autonomic ganglia just as in the case of nicotine, because these drugs have in common a piperazine nucleus in their chemical structures. In addition hetrazan is found to have also a minor analgesic and antihistaminic action.抄録全体を表示PDF形式でダウンロード (10241K) -
灌流および小動物環界液に藥物を與えた場合の實驗小川 和榮1952 年 48 巻 1 号 p. 25-33,en2
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリー(1) On the assumption that a certain concentration of drugs at the point of action produces a selected effect to organism when the drug in the various concentration streams through the blood vessel, the relation between concentration and the time needed to produce their effects can be expressed by the formula kt=logC/C-C1… (A)
t=the time, C=external concentration of drugs, k=constant different according to the empirical system and C1=threshold concentration which can be measured directly. The above formula (A) can be replaced by the formula, Ct=at the great part of that time-concentration curve, but Cmt=k… (B) may be considered as the general formula. (2) Observing the effect of drugs on small animals in a certain various concentration of drugs after the absorption of drugs through the surface of their bodies, we can get the above formula (A) or (B) as time-concentration curve. (3) My experimental results showed that the formula (B) had m=1 as the value over a wide range of concentration of drugs and on the other hand the value changed abruptly to become about 0.7 (0.58-0.8) at where concentration was large, but only strophanthin was m=0.26. In the case of perfusing experiment by drugs which seemed to act as protoplasmic poisons, the value of m was 0.65 or 0.7 all over the whole. (4) From the experimental results it may be said that drugs should reach the point of action in organism considerably slower than the rate of uptake by the surface from the external milieu. It can be concluded that in the case of the reversible action of drugs, i. e. in the most cases of drug actions the drugs should produce the certain effect when the certain concentration of drugs have been attained at the point of action mainly by adsorption.抄録全体を表示PDF形式でダウンロード (1614K) -
長谷川 善雄1952 年 48 巻 1 号 p. 34-41,en2
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーThe time needed to produce the selective effects at 10°, 20°, 25°, 30°, and 35°C was measured to find temperature coefficient on pharmacological action. The animals used for the experiment were the toad (Bufo vulgaris) and a kind of the freshwater fish (Ophicephalus argus Cantor), and were perfused their their hearts and the muscle of hind limb of the toad with drugs. Digitalis glycoside, g-strophanthin and acetylcholine were used as drugs for the heart perfusion, and acetylcholine, caffeine and guanidine for the muscle perfusion. All these drugs were in a wide range of their different concentrations. With those experiments the following conclusions were obtained : (1) The temperature coefficient of this empirical system indicates its minimum and nearly equal numerical value at the range of about 15°C to 30°C. However the temperature coefficient increases rapidly at the lower or higher than the range of the above temperatures, and all the changing points seemed to be at a certain temperature between 10°C and 15°C, or 30°C and 35°C. (2) According to the increase of the concentration of drugs, the temperature coefficient was apt to increase slowly. (3) Under the above mentioned facts, further, the following numerical values turn up when geometrically averaging a series of six results at each concentration and temperature. The above list indicates fairly resembling numerical value for each case. Each numerical value, however, was slightly different from others because of different animal species, Organs and drugs. (4) The temperature coefficient measured by the effect of drugs may be mainly due to a difference of temperature in adsorption rate of drugs, by which a satisfactory explanation will be given to that phenomena. It may therefore be said that drugs can produce a certain effect without any relation of temperature when a certain concentration of drugs is attained at the point of action. (5) The effect of acetylcholine on the heart and the muscle did not provide, the temperature coefficient. Assuming that acetylcholine in the tissues receives a rapid resolution, it may be understood that any difference of temperature can not be recognized in the time of action of acetylcholine, because acetylcholine rapidly reaches the tissues by the higher temperature and, at the same time, the destruction by cholinesterase proceeds quickly.抄録全体を表示PDF形式でダウンロード (1609K) -
菅 陞1952 年 48 巻 1 号 p. 42-51,en3
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーThe changes of respiration, blood pressure, leucocyte count, intestine motility, EEG, etc. after electroshock were analytically investigated. From the results it is concluded that they are either due to convulsion itself or due to stimulation of the autonomic nervous center. The drugs like curare depress the convulsion state, while those like ergotamine modify the autonomic effect, and the central stimulants or narcotics give some influences upon both of these effects. In general, however, the electroshock is so powerful a stimulus for the living organism that the influences of drugs are not so remarkable.抄録全体を表示PDF形式でダウンロード (8432K) -
第2報 諸種驅虫藥の豚蛔虫に對する効力の比較橋本 芳孝1952 年 48 巻 1 号 p. 52-64,en4
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーThe actions of the following drugs were examined on Ascaris suillus. Drugs tested : Santonin, hexylresorcinol, iso-amylresorcinol, oil of chenopodium, thymol, naphthaline, camphor, tetrachlorethylene, carbon tetrachloride, pbenzylphenol (allegan), allantolactone (helenin), xanthoxylum-extract and seven of thirty-six sulphides which exerted some anthelmintic effects on the earthworm, such as phenylthio-urethane, phenylthiol-urethane, o-methylphenylthio-urethane, p-oxyphenylthio-urethane, o-oxyphenylthio-urethane, acetylphenylthiol-urethane, and butyl ester of phenylthiocarbamic acid. Result : Hexylresorcinol shows in general the most powerful and immediate anthelmintic action on ascaris, while thymol, iso-amylresorcinol, oil of chenopodium, p-benzylphenol, and o-methylphenylthio-urethane have also the same actions but somewhat weaker. Among them oil of chenopodium and p-benzylphenol are less toxic than hexylresorcinol and in their low concentrations these anthelmintic effects are rather stronger than hexylresorcinol so that p-benzylphenol, newly introduced, seems likely to have the practical value for clinical use.抄録全体を表示PDF形式でダウンロード (2444K) -
山本 擴1952 年 48 巻 1 号 p. 65-90,en4
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーA series of experiments was performed on the effect of some antibiotics (penicillin G, dihydrostreptomycin, streptomycin calcium chloride complex, chloromycetin, aureomycin and pyrimidin-penicillin) on the blood-sugar level in the normal, hyper- or hypoglycemic rabbit by Hagedorn-Jensen's method. Result : (1) No effect was observed by penicillin and chloromycetin on the blood-sugar level, and little effect by dihydrostreptomycin and pyrimidin-penicillin. (2) Streptomycin calcium chloride complex exerted a slight rise in this level. It seemed probably to be ascribed to the histamine-like action involved when administered.streptomycin. (3) Aureomycin decreased slightly the blood-sugar level. This hypoglycemia turned over to normal by vitamin B complex, especially by vitamin B2 as well as niacin. Briefly to say these antibiotics studied here have no significant effects on the blood-sugar level of rabbits.抄録全体を表示PDF形式でダウンロード (4298K) -
1952 年 48 巻 1 号 p. a4
発行日: 1952年
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (131K) -
1952 年 48 巻 1 号 p. a1-a37
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (6683K) -
報告要旨1952 年 48 巻 1 号 p. a38-a62
発行日: 1952/02/20
公開日: 2011/09/07
ジャーナル フリーPDF形式でダウンロード (4665K)
- |<
- <
- 1
- >
- >|