The actions of the following drugs were examined on
Ascaris suillus. Drugs tested : Santonin, hexylresorcinol,
iso-amylresorcinol, oil of chenopodium, thymol, naphthaline, camphor, tetrachlorethylene, carbon tetrachloride,
pbenzylphenol (allegan), allantolactone (helenin), xanthoxylum-extract and seven of thirty-six sulphides which exerted some anthelmintic effects on the earthworm, such as phenylthio-urethane, phenylthiol-urethane,
o-methylphenylthio-urethane,
p-oxyphenylthio-urethane,
o-oxyphenylthio-urethane, acetylphenylthiol-urethane, and butyl ester of phenylthiocarbamic acid. Result : Hexylresorcinol shows in general the most powerful and immediate anthelmintic action on ascaris, while thymol,
iso-amylresorcinol, oil of chenopodium,
p-benzylphenol, and
o-methylphenylthio-urethane have also the same actions but somewhat weaker. Among them oil of chenopodium and
p-benzylphenol are less toxic than hexylresorcinol and in their low concentrations these anthelmintic effects are rather stronger than hexylresorcinol so that
p-benzylphenol, newly introduced, seems likely to have the practical value for clinical use.
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