日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
50 巻 , 6 号
選択された号の論文の10件中1~10を表示しています
  • 上杉 榮
    1954 年 50 巻 6 号 p. 495-501,en41
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    種々なFlavone化合物の藥理學的作用に就ては, 1927年より數年聞に渉り福田教授一門の入々1) (輻田, 河野, 赤松, 椎名, 村尾, 富士川) により詳細に報告せられて居り, 其の後小池2) は利尿作用に就て, v.Jeney, Czimmer, Mekes3) 等は循環器系に野する作用に就て報告して居るが, それ以後FIavone化合物に對する藥理學的研究は餘り省りみられなかつた.
    然るに1944年Griffith, Couch & Lindauer4) 等はFlavone配糖體の一つであるRutinはVitamin Pの本態であるHesperidinと化學的に近似しているばかりでなく, capillary stabilizerとして同様な作用を有する事を明かにし, 更にShanno5) により此の點が確認されるに至り, 爾來動物實驗或は臨牀的に廣く檢討が加えられた.然し之等の多くはFlavone化合物のcapillary stabilizerとしての作用に關したものであり, 系統的に藥理學的作用を檢したものは尠い.加藤6) はRutin, Quercetinに就て福田教授一門の業績を追試すると共にcapillary stabilizeτとしての作用も比較檢索している.
    然し多くのFlavone化合物は水に難溶であり, 特別の溶剤を以て溶液とし臨牀並びに實驗に用いられておるが, 最近卯尾田は落葉松からQuercetinの還元型物質を抽出, 之をLarixinと命名した.本物質は化學的にDihydroquercetinで氷溶性であり, 然も坂本7), 山崎8) は中村G指導の下に本物質が局所適用或は静脈注射によつてArthus現象を抑制し, 血管を強化する事を朗かにしている.
    然し乍ら本物質の々な藥理學的作用に關しては全く報告がない.
    茲に於て私は本物質の藥理學的作用を檢し, 二, 三の點ではRutinとの比較も試みたので其の結果を報告する.
  • 上杉 榮
    1954 年 50 巻 6 号 p. 502-522,en41
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    1) Rutin, quercetin and dihydroquercetin (D.H.Q.) give diuretic action to normal and hydrated rabbits. 2) The mode of diuretic action is different in rutin, quercetin and D.H.Q. respectively. D.H.Q. shows its action shortly after injection and rutin at a later stage, while quercetin shows its action at both early and later stages. 3) The diuretic action can be observed also in rats slightly. 4) The effects of combined use of rutin, quercetin and D.H.Q. with caffein, g-strophanthin, or Igrosin are not identical. Simultaneous application of quercetin with caffein or Igrosin; and D.H.Q. with Igrosin produce a synergistic diuretic action. The antidiuretic action of g-strophanthin is antagonized by the use of these flavone compounds. 5) These flavone compounds cause hydremia in rabbits. Quercetin shows the most marked action of these compounds. 6) These flavone compounds cause a slight fall in blood pressure, without causing any influence upon a kidney volume. 7) Quercetin accelerates the respiration of kidney slices of mice, while no evident action is observed in the case of rutin or D.H.Q.. 8) The combination of quercetin with caffeine, g-strophanthin or Igrosin and that of D.H.Q. with Igrosin increase the rates of respiration of kidney slices. But the combined application of rutin with caffein or g-strophanthin decreases the tissue respiration. 9) Rutin, quercetin. and D.H.Q. are rapidly excreted in urine. After intravenous injection, from 20-50% of administered rutin or quercetin can be recovered in the urine and from 10-20 % of D.H.Q
  • 古川 聰
    1954 年 50 巻 6 号 p. 523-535,en42
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    私は山本1) とともに乾燥ジギタリス・プルプレア葉より各種有機溶媒で強心物質を抽出したもののうち, メタノールエキスに最も多く強心物質が含まれていることを知つた.故に以下, 特別の場合を除きジギタリス葉の實驗にはすべてメタノール抽出を行つたのである.
    溶媒の濃度と有効成分の抽出能率との關係については, Rosenkranz2) が水よりもエチルアルコールによる抽出がよく, 50~70%アルコール抽出エキスが最も強力に作用するといつている.
    從來, ジギタリスに對する蛙の感受性に季節的變動があり, 特に夏季は感受性が高いといわれ, また蛙體重の大小にも感受性の差があるといわれているが, これらの問題にもふれて實驗を進めた.
    強心配糖體の安定劑として, さきに山本はp-オキシ安息香酸ブチルおよび1%ブドウ糖の添加をあげたが, 酸性亞硫酸ナトリウムを加える者もあり, また溶媒としてプロピレングリコールがジギタリスの溶媒に用いられていることもあるので, それらの適否を檢べた.
    また私は, プルプレア葉メタノールエキスを酢酸エチルエステルで處理すると, その可溶分が速効性に偏し原葉既存の遲効成分が欠けていることを知つたので, 酢酸エチルエステル使用のことについても詳しく實驗した.すなわち, 大體原葉既存遲速有効成分の割合, サポニン物質除去方法, 水素イオン濃度と配糖體失効との關係および有効成分保存方法について比較檢討した.
    ジギタリス・ラナタ (邦産) よりのDigitalisおよびジギトキシン (U. S. P.) を實驗した結果や, ジギタリスの人における効力の發現時間に疑義があるので, 抽出成分を健康人に經口投與して張心および利尿作用を心電圖, 脈搏, 尿量などについて觀察した.
    要するに.ジギタリスに關する藥理學的, 藥學的研究はその歴史の古さから複雜多岐にわたるので, 私はプルプレア配糖體の研究を最後の日的として, 種々派生的な問題にふれて實驗した.
  • 瀬川 富郎
    1954 年 50 巻 6 号 p. 536-549,en42
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    The investigation on the amounts of adrenaline (A) and noradrenaline (N) in the suprarenal gland and in the blood after administration of mecholyl, acetylcholine, nicotine and the splanchnic stimulation was performed. Rat's blood-pressure and rabbit's intestine were used to estimate the contents of A and N in the isolated rabbit's suprarenal gland, the Gaddum's formula being applied for calculation. The proportions of A and N liberated from the suprarenal gland were determined by the method. of Bülbring and Burn, using a denervated cat's nictitating membranes. Under the conditions mentioned above an increase of N and a decrease of A was observed. From these results it may be considered that N plays an important part as an adrenergic transmitter.
  • 上島 孝治
    1954 年 50 巻 6 号 p. 550-564,en42
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    Using a modified Hot-plate Method by Woolfe and Macdonald, a detailed investigation was made as to the reactions exerted in mice to the painful heat stimulus, which were divided then into two groups, i.e. the tremor as a first reaction ; bending or lifting up the hind limbs, etc. and the second reaction ; licking the sole of back paw or jumping, etc.. From the results of experiments in normal as well as in spinal mice it has been proved that the first reaction is of spinal nature and it disappears ever after spinal depressant drugs, while the second reaction is derived from supraspinal origin. The more reliable estimation will be, therefore, obtainable by making the second reaction as the algesimetric standard of drug effects. Further, other essential problems as to the algesimetric methods are also discussed.
  • 手島 晧一
    1954 年 50 巻 6 号 p. 565-577,en43
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    The local anesthetic activities of the anti-histaminic drugs have been studied. on the skin of frogs (hind legs) and cornea of rabbits. 1) The anti-histaminic drugs, such as Restamin (Benadryl), Pyribezamine, Anergen (3115 RP) and Anahist, have an apparent local anesthetic action on the skin of frogs and cornea of rabbits. The order of anesthetic potency of these compounds is as follows : Anergen>Restamin>Pyribenzamine>Anahist. The local anesthetic potency is more apparent at pH 7.2 of solution than at pH 6.6. 2) Anti-histaminic drugs intensifies the local anesthetic action of another anti-histaminic or of local anesthetics on the skin of frogs. 3) When anti-histaminics in, high concentration are applied with local anesthetics to the cornea of rabbits, the duration of anesthesia decreases, but anti-histaminics in low concentration augment the anesthetic activities of local anesthetics. 4) The permeability rate of procaine through the cornea of rabbits is increased by Restamin and Pyribenzamine either in vivo or in vitro. 5) The permeability rate of anti-histaminic drugs (Restamin, Pyribenzamine) and local anesthetics (Procaine, Narcaine) are influenced by pH of the applied solution.This rate is higher at pH 7.2 than at pH 6.6.
  • 内藤 史朗
    1954 年 50 巻 6 号 p. 578-592,en43
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    The influences of liver artery ligation and of liver extirpation on the alcohol metabolism were observed by making experiments on rabbits. Ethyl-, methyl-, and isopropyl-alcohol were administered intravenously and the concentration of these alcohols in blood were determined every one hour. The results were as follows : 1) The oxidation of ethyl-alcohol was scarcely influenced by the liver artery ligation. It was clearly restrained by the extirpation, yet still went on after the operation. 2) In the case of methyl-alcohol, the oxidation was nearly checked by the ligation, and completely by the extirpation 3) The oxidation of isopropyl-alcohol was restrained in some degree by the ligation, and was stopped by the extirpation. Of these alcohols, ethyl is the most easily oxidized, next comes isopropyl, and the last methyl-alcohol.
  • 熊谷 洋, 油井 亨, 小川 喜一, 大賀 晧
    1954 年 50 巻 6 号 p. 593-601,en43
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    A method has been devised for the perfusion of a dog's head connected to its body only by vago-sympathetic trunk and spinal cord. In order to separate completely the vascular system of the head from the body, it was shown to be necessary to transect all the skin and muscles around the neck at the level of occipito-atlantal joint and to occlude A. spinalis anterior and Sinus columunae vertebralis in vertebral canal. The completeness of the blockade of the blood circulation between head and body was checked by the injection of Evan's blue or adrenaline in either side of the circulation. The time course of survival and reactivity to drugs of the brain was also investigated. From the result obtained in 30 experiments it has been convinced that this method is one of the most excellent methods to observe the direct action of drugs upon brain centres.
  • 油井 亨
    1954 年 50 巻 6 号 p. 602-608,en44
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
    By means of our method (see this Breviaria, No. 63), the central effect upon blood pressure and respiration of, adrenaline and its homologues injected into the perfusion circuit 'of dog's head was investigated. Adrenaline reduced the systemic blood pressure and the respiratory, movement of the recipient dog. By a given dose of adrenaline, the degree of the fall was shown to be roughly proportional to the initial level. This central inhibitory effects of adrenaline upon both the blood pressure and the respiration were observed not only during the adjustment of the elevated perfusion pressure by adrenaline to preinjection level but also after denervation of vagus and/or carotid sinus nerves. N-Methylbenzedrine and ephedrine given intraarterially to the head, elevated the systemic blood pressure gradually, the effect of the latter being remarkably weaker than the former. The former stimulated the respiration, whereas the latter did not show any stimulation but caused inhibition. 'Both of them dilated slightly the blood vessels of the head.
  • 1954 年 50 巻 6 号 p. a235-a258
    発行日: 1954年
    公開日: 2011/09/07
    ジャーナル フリー
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