日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
66 巻, 4 号
選択された号の論文の10件中1~10を表示しています
  • 佐藤 哲男, 吉田 〓一, 小倉 保己, 諸井 佳代子
    1970 年 66 巻 4 号 p. 387-393
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    Correlation between cholinesterase (ChE) inhibition, miosis and tryptophan pyrrolase (TP) activity in EPN-treated rats was investigated, and following results were obtained.
    1) Inhibit ion of serum ChE was initiated at 1h and continued untill 24h after EPN administration, however, maximum response of miosis and increase in TP activity were observed 6h after treatment and gradually recovered to initial levels within 24h. These observations indicated that ChE inhibition was evoked prior to changes in pupil reaction and TP activity.
    2) Increase in TP activity was inhibited by pretreatment with either β-adrenergic blockers, propranolol and DCI or atropine and PAM, moreover, adrenalectomy abolished completely the increase in TP activity. It is likely, therefore, that administration of EPN did stimulate the secretion of glucocorticoid from adrenals through autonomic nervous system.
  • In vitroにおける非ステロイド性抗炎症薬の検定への試み
    相沢 義雄, 岩崎 守男
    1970 年 66 巻 4 号 p. 394-399
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    The inhibitory action of nonsteroidal anti-inflammatory drugs on the ATPase activity and inflammatory edema were studied.
    The inhibitory rate of ATPase activity and inflammatory edema by nonsteroidal anti-inflammatory drugs were well correlated.
  • 瀬川 富郎, 車 勇, 高塚 勝哉, 高木 博司
    1970 年 66 巻 4 号 p. 400-407
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    Subcellular distribution of 5-hydroxytryptamine (5-HT) in rabbit brain stem was investigated by the technique of differential and density-gradient centrifugation. The present study confirmed the finding that 5-HT was principally found in crude mitochondrial fraction (P2). Further subfractionation of P2-fraction revealed that the high concentration of 5-HT was found in P2B- and P2V-fraction although considerable amount of 5-HT was also found in P2D- and P2S-fraction. Electron microscopic examination showed that P2- and P2V-fraction consisted largely of nerve-ending particles and synaptic vesicles, respectively.
  • 鈴木 守, 豊島 泰光
    1970 年 66 巻 4 号 p. 408-416
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    The increased capillary permeability (and non-blued area) produced by the intracutaneous injection of alcohols in rabbits were investigated.
    1) The ch ange of permeability by dihydric alcohols (C2 to C6) were proportional to the length of their carbon chain.
    2) The increased permeability and the size of non-blued area were inversely proportional to the numbers of hydroxyl residue in lower alcohols.
    3) There were not or scarcely differences among the responses formed by some position isomers of dihydric alcohols.
    4) Polyoxyethylene glycols of various molecular weights at a constant molar concentration leaded the indistinguishable extents of the increased permeability, and a similar relationship was found in the formation of non-blued area by these glycols at a same concentration in percent.
    5) The pretreatment of diphen hydramine inhibited partialy the increase of permeability by lower alcohols, but not those by higher alcohols.
    6) The increse of permeability by alcohols was not effected by the pretreatment of salicylate, glycyrrhizin and cortisone.
    7) The change of permeability by alcohols seemed to be related with their oil-water partition coefficient and their surface activity.
    8) The mechanisms on local action of alcohols were discussed from the results in previous and this papers.
  • 小林 雅文, 今井 元興, 堀部 正行, 佐野 光章, 野村 寿男, 矢沢 利典
    1970 年 66 巻 4 号 p. 417-426
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    Previous works showed that isolation induced hyperactivity of brain ChE of mice.
    Present study was carried out by measuring the effect of exogenous ACTH on such hyperactivity and aggressiveness induced by isolation.
    Male albino D. D. O mice weighing 15 g were employed through all the experiments. Each animal was put in plastic cage for a period of 8 weeks. The size of cage for isolation is 10×10×11 cm and for aggregation (5 animals for a cage) is 19×12×12 cm. The walls were painted in black in such a way that the animals could not have visual contacts. Animals were fed a normal balanced diet “ad libitum” and administered with following drugs every two days.
    Experimental gr oups were consisted as the following;
    A) Isolated mice
    1) The group administered with ACTH (10 J. P. U./kg i. p.) ?? ACTH-A
    2) The group administere d with solvent of ACTH (i. p.) ?? Controls-A
    B) Aggregated mice
    1) The group administered with ACTH (10 J. P. U./kg i. p.) ?? ACTH-B
    2) The group administere d with solvent of ACTH (i. p.) ?? Controls-B
    The degree of aggressi veness was evaluated according to the method described by Allee-Scott and from such degree animals were classified into “victorious mice” and “defeated mice.” The test was performed every Saturday for a period. At the end of the period of isolation and aggregation animals were decapitated in different times (0′, 15′, 30′, 60′, 120′ after eserine treatment (0.2 mg /kg i. p.) and biochemical procedure were carried out in these brains by measuring ChE activity with the method described by Hesterin.
    Results;
    1) The relation between the period of isolation and aggressiveness:
    Aggressiveness of ACTH-A was markedly enhanced up to 6 th week of isolation and after this week such enhancement was slowley become, while aggressiveness of controls-A was rapidly elevated up to 8 th week of isolation and after this week such rapidity was markedly declined.
    2) The influence of isolation on body weight:
    Body weights of the aggregated mice of both group were found to be significantly lower than the isolated mice of which the victorious mice were significantly greater than the defeated mice in either case.
    3) Brain ChE activity:
    a) Hyperactivity of bra in ChE in isolated mice were found in either case.
    a) Hyperactivity of brain ChE in isolated mice were found in either case.
    b) Administration of ACTH declined this enzymatic activity in different degree in either isolation or aggregation.
    c) Isolation of mice inhibited slightly the effect of eserine on above enzymatic activity.
  • ―各種標本における増強作用―
    石田 行雄, 守時 英喜
    1970 年 66 巻 4 号 p. 427-434
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    In previous papers, the potentiating effect of choline to the contractile action of phenylacetate was found on the isolated guinea-pig ileum. In this paper, this potentiating effect was examined on other isolated preparations, such as other each part of gut, vas deferens and taenia coli of guinea-pig, uterus and stomach fundus of rat and frog rectus. It was showed that phenylacetate with choline were able to produce the contractile responses on all these preparations on which ACh had responses, and then the blood depressor action in dog which seemed ACh-like response. It was supposed that the mechanism of responses produced by phenylacetate with choline might be the formation of ACh or releasing ACh. These phenomena were named Acetate-Choline coupling (Ac-Ch coupling) responses.
  • El-マウスの運動,性差または刺激時刻と痙攣発症の関係
    秦 多恵子, 村上 哲男, 喜多 富太郎
    1970 年 66 巻 4 号 p. 435-441
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    El-マウス痙攣発症の要因についていくつかの検討を加え,次のような結果を得た.
    1)El-マウスの痙攣発作出現後の運動(振とう刺激)は,痙攣に抑制的に働くようである.
    2) El-マウスの痙攣は雄より雌の方が起こり易かった.
    3) El-マウスの痙攣は午前中より夕刻の方が起こり易かった.特に雌においてこの傾向が大であった.
    4) El-マウスにおける痙攣誘発の同調性は雄より雌における方が大であった.
  • 庄 貞行, 杵鞭 宏育, 江頭 亨, 関 政子, 山田 桃子, 篠田 徳三
    1970 年 66 巻 4 号 p. 442-448
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    Monoamine oxidase (MAO) in hog kidney was found mainly in mitochondrial fraction and about 60 % of the enzyme in mitochondria was solubilized by a treatment of 1 % sodium cholate and ammonium sulfate fractionation. The specific activity of purified MAO was about 10-fold than that of the homogenate. PS maximum of the purified MAO was found at 2.0 and pH optimum was found at 8.0 in case of tyramine used as substrate. The administration of Fe++ and Cu++ in the system caused inhibition, however, NaN3 caused marked activation of the enzymic activity.
  • 喜多 富太郎, 秦 多恵子, 村上 哲男
    1970 年 66 巻 4 号 p. 449-457
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    1) El-マウスの痙攣発症に関するマウスの2者または3者の相互関係を多数例について整理したところその不発作率と同調率の間に一定の関係が存在することがわかった.
    2) この関係に対し,一般薬理作用の全く認められない微量の中枢作用薬物を予め投与しておいた場合の影響を調べた.その結果中枢興奮剤を与えた場合には同調性が多くなり,逆に中枢抑制剤を与えた場合には不発作率が大きく同調性が少なくなった.
    3) amphetamine投与によって2~3者関係特に2者関係はいずれも正常範囲から外れ,しかもある一定の範囲に収束することが明らかとなった.
  • 小野寺 威, 笠原 明, 石原 正直, 小河 秀正, 大島 康夫
    1970 年 66 巻 4 号 p. 458-469
    発行日: 1970年
    公開日: 2007/03/29
    ジャーナル フリー
    Furazabol, a new anabolic steroid, inhibited a rise in cholesterol levels in the serum and liver induced by cholesterol feeding, although its effects on phospholipids, triglycerides, and free fatty acids were not marked. Fatty acid compositions of serum esterified cholesterol and triglycerides were not so much affected by the furazabol treatment. Furazabol has been expected to possess the therapeutic effect on atherosclerosis, that is, the progression of atheromatous changes was significantly inhibited by the treatment with this compound. In addition, furazabol clearly lightened fatty degeneration of the liver.
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