日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
51 巻 , 2 号
選択された号の論文の15件中1~15を表示しています
  • 小枝 武美
    1955 年 51 巻 2 号 p. 79-83,en11
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The author has examined the effects of central stimulants and depressants on the concentration of calcium in the various parts of the central nervous system of guinea-pigs and has found that Ca is conspicuously concentrated in the mesand the diencephalon at the time of excitation or sleep induced by the medicaments. This high accumulation of Ca is proportional to the degree of excitation or sleep and returns gradually to normalcy along with the recession of such states.
  • 飯田 元男
    1955 年 51 巻 2 号 p. 84-90,en11
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The author has observed the response of isolated thoracic ducts of cows against various chemicals by Magnus's method. for the purpose of determining the structu ral function of the wall of thoracic duct and arrived at the following results : 1) The thoracic duct is capable of spontaneous movement, but moves in such a manner only on rare occasions. The spontaneous movement then is in the form of a periodical pendulum movement. 2) The tension of isolated thoracic duct is accentuated by sympathetic as well as parasympathetic nerve stimulants showing no antagonism between these two sorts of stimulants. This fact may be easily interpreted upon considering the histological structure of thoracic duct. Be the two kinds each of the adventitial and the medial muscle bundles under the control of either the sypathetic or the parasympathetic nerves, it is quite understandable that the tension rises with use of stimulants and falls with the use of either sympathetic or parasympathetic depressants as shown in the author's experiments.
  • 森田 淑子
    1955 年 51 巻 2 号 p. 91-93,en11
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The effect of aldehydes, including d-trans-7-aldehyde-π-apocamphor (vitacamphor), on the activity of dehydrogenase of rat tissue homogenates and of bovine heart muscle pulp was observed. The aldehydes such as vitacamphor, 10-oxocamphor, benzaldehyde, anisaldehyde and furfural, considerably decreased the activities of dehydrogenases of the brain and heart homogenates, and of lactic and citric dehydrogenase of the heart. Vitacamphor showed less inhibitory effect on these enzymes of the kidney and liver than other aldehydes. Two aldehydes, cinnamic aldehyde and citral, caused a strong inhibition on the dehydrogenase of tissue homogenates and lactic, citric and some other dehydrogenases, while citronellal, heptaldehyde and acetaldehyde showed only slight effects on dehydrogenase activities.
  • 森田 淑子
    1955 年 51 巻 2 号 p. 94-106,en12
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    1) Benzaldehyde, anisaldehyde, and other aldehydes, so far as was found in the present tests, are more readily oxidised by xanthine- and aldehyde oxidase preparations, than d-trans-7-aldehyde-π-apocamphor (vitacamphor). 2) Decreased. dehydrogenase activities induced by aldehydes returned to the normal level by the addition of cysteine, glutathione and ascorbic acid. 3) Vitacamphor underwent equimolar combination with cysteine, forming an aldehyde-thiol compound. It also combined to a certain extent with glutathione, but not with ascorbic acid. 4) Vitacamphor and other aldehyde appeared to catalyze the non-enzymic oxidation of cysteine. 5) Ascorbic acid with the dehydrogenase systems seems to participate to some extent in the reduction of vitacamphor.
  • 江橋 節郎, 武田 文子, 熊谷 洋
    1955 年 51 巻 2 号 p. 107-110,en12
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    ATP-dependent relaxing factor of glycerinated muscle fibres isolated from skeletal muscle consists of two components, the one is contained in 10-20 g/dl fraction of ammonium sulfate and the other in 30-40 g/dl. Each one of them, fractionated twice by ammonium sulphate, has little, if any, activities by itself. The collaboration of these two components, however, give rise to strong relaxation comparable to that by the original factor.
  • 武田 文子
    1955 年 51 巻 2 号 p. 111-122,en12
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    Chief attention of this article is focused on the differentiation between PC-dependent “relaxing factor” (PC=Phosphocreatine), identified as creatine phospho-kinase by Lorand, and ATP-dependent one, similar to or identical with Marsh-factor. Results obtained by the present author proved that these two factors are quite different from each other. The present author is of opinion that creatine phosphokinase-PC-ATP system added form without has not a remarkable relaxing effect, if not aided by some other factors. The mechanism of contraction-relaxation cycle in muscle was discussed.
  • 南雲 猛
    1955 年 51 巻 2 号 p. 123-131,en12
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The excised liver of guinea pig was perfused with blood and Ringer solution containing digitoxin and the digitoxin uptake of the liver was determined by assaying the potency of perfusion fluid and overflow using guinea pigs. The following conclusions were obtained : Digitoxin is gradually transferred to or absorbed by the liver from the fluid during perfusion by physiological activity of the liver itself, but not by diffusion. The extent of activity is suggested to be extremely large, since the maximal amount of digitoxin “captured” by the liver which was saturated with digitoxin, was calculated at 0.12 mg or over per gram liver.
  • 深瀬 京
    1955 年 51 巻 2 号 p. 132-154,en13
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    Intravenous administration of digitalis-preparations (Digitoxin, Digitoxigenin, Digoxin, Strophanthin, Cedilanid and Digicorin-fraction) produced the so called. “Vomiting curve” of the stomach-movement of pigeons. After a definite time it recovered to its normal condition. There is no parallel relation among the vomiting-dose, dose of slowing of heart rate and L.D. (U.S.P.). When the vomiting curve and the slowing of heart rate recovered to normal, Digitoxin effect was the slowest, Digitoxigenin effect was most quickened and Cedilanid and Digicorin-fraction remained moderate. When Digitoxin was injected, the T wave of the E.K.G. showed the lowest value. In the case of Digitoxigenin, the depression of the T wave was still indicated after recovering from the slowing of heart rate. There was no depression on the T wave even when Digicorin-fraction and Cedilanid caused the slowing of heart rate. It can be assumed that the mechanism of vomiting and that of heart rate's slowing are not the same.
  • 森川 正利, 宮崎 郁雄
    1955 年 51 巻 2 号 p. 155-163,en13
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The electrical properties (ζ-potential) of the interface have been studied in order to learn the biological significance of the surface activity in pharmacological actions. The rabbit red cells were used to measure the ζ-potential. This is known from the following formula : V ζ·D·I/η·K (V : electrophoretic velocity, D : dielectric constant, I : electric current, η : viscosity, K : conductivity). The results : Tween 80, G 2162, Lazal, Aerosol IB, sod. cholatate and saponin decreased the electrophoretic velocity. On the contrary, Span 20 and sod. lauryl sulf. increased it. The changes in velocity can be regarded as the changes in ζ-potential of red cell surface, because it was ascertained by other experiments that the viscosity, conductivity and dielectric constant were not altered by surfnce active agents in lower concentrations used in the experiments on electrophoresis.
  • 山岡 正幸
    1955 年 51 巻 2 号 p. 164-172,en13
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    1) Some pharmacological actions of histidine were investigated. 2) The adrenalin-sensitization by histidine was shown only in the perfused blood vessel of rabbit ear. 3) The negative dose of histidine had influence upon the adrenaline determination by silicomolybdic acid. 4) Not only antagonism but also synergism between histidine and acetylcholine were demonstrated in the excised intestine of rabbit. 5) Histidine (1/500-1/1000 mol) had no influence on cholinesterase, histaminase and amine oxidase. 6) Using the Folin-Wu method, the determination of histidine by adrenaline was confirmed. 7) In alkaline medium histidine accelerated the adrenaline oxidation.
  • 山口 滋嗣
    1955 年 51 巻 2 号 p. 173-189_2,en14
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    A slight inhibition in the development of chick embryo was noted with the injection of NaI solution into developing hens' eggs, especially with the injection of highly concentrated solution. No malformation in the embryo was recorded, and the eggs hatched perfectly with the exceptions in the cases with 20 mg and 30 mg of NaI. The excretion of iodine into the allantoic fluid was found extremely poor, showing the highest value on the 12th day of incubation. The highest rate of excretion was 17.29% recorded in the case received the injection of 10 mg of NaI. In the cases with the injection of 5 mg of NaI, the contents of iodine in the brain, heart and liver were found increased by the above order compared with the untreated control cases, and the weight of each of the above organs were also found increased. As to the histological findings of the liver, regressive degenerations such as vacuolar degeneration, fatty degenerations and necrosis of the hepatic cells were recognized in the cases treated with NaI exceeding 1 mg.
  • 山口 滋嗣
    1955 年 51 巻 2 号 p. 191-198_2,en14
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    When developing hens' eggs were injected with 1 mg of NaI combined with 10 mg of PAS Na-salt or with 1.5 mg INAH, the development of the chick embryo was slightly inhibited compared with the controls in the cases of the combination with PAS, whereas the development was found generally similar to the control in the cases of the combination with INAH. In both cases, the hatchings were perfect without any malformation. The highest excretion of iodine was recorded on the 15th day of incubation in both cases, showing higher excretion when compared with the cases of single administration of 1 mg of NaI. The excretion of the total PAS was found increasing as the incubation period goes on as seen in the cases with INAH. A for the histological findings in the liver of chick embryo, no particular changes were noted excepting a mild vacuolar degeneration of the liver cells.
  • 藤村 一, 上島 孝治, 小柳津 隆, 石川 正昭
    1955 年 51 巻 2 号 p. 199-207,en14
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
    The pharmacological actions of aminocyclohexane derivatives were studied on the animal as well as human body and 1-ethyl-l-benzoxy-2-dimethylaminomethyl-cyclohexane HCl was found remarkable in analgesic action and very slight in side action, the mode of action of which differed fairly from those of morphine and Ohton [1, 1-di (2'-thienyl) -3-dimethylaminobut-1-ene HCl]
  • 1955 年 51 巻 2 号 p. e1
    発行日: 1955年
    公開日: 2011/09/07
    ジャーナル フリー
  • 1955 年 51 巻 2 号 p. a81-a107
    発行日: 1955/03/20
    公開日: 2011/09/07
    ジャーナル フリー
feedback
Top