日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
50 巻 , 1 号
選択された号の論文の13件中1~13を表示しています
  • 赤堀 和一郎
    1954 年 50 巻 1 号 p. 1-7,en1
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    There were many sweet compounds in m-nitroaniline derivatives, but among them many toxic compounds were found. Symptoms of this poisoining and its lethal dose (LD 50) were observed in mice, and the influence on respiration and blood pressure was investigated in rabbits. 1. Toxicity of 2-amino-4-nitrophenol alkyl ethers increased in accordance with solubilities of these hydrochloride salts. 2. It was recognized that m-nitroaniline induced the toxic effect on blood and liver, while 2-amino-4-nitrotoluene induced the toxic effect on the liver and 2-amino-4-nitrophenol alkyl ethers on nervous system. 3. 2-amino-4-nitrophenol was most soluble in above mentioned compounds, but the toxic effect was relatively slight. It seemed that this was due to the easily combining quality of the phenolic OH group with the glucuronic acid or sulphuric acid which was easy to be detoxicated. 4. It seemed that the toxic effect of 2-amino-4-nitrophenol alkyl ethers were caused by its phenolic alkyl ether structure rather than by its m-nitroaniline's. 5. In rabbits, a fall of blood pressure was caused and respiration was suppressed for a short time after injecting m-nitroaniline and 2-amino-4-nitrophenol methyl ether etc. After injecting 2-amino-4-nitrophenol and p-nitrophenol, blood pressure fell for a while and respiration remarkable excited. It seemed that these results were influenced by the phenolic OH group.
  • 赤堀 和一郎
    1954 年 50 巻 1 号 p. 8-16,en1
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    m-Nitroaniline derivatives were given to mice Per os and internal organs of these mice were patho-histologically examined, and remarkable changes were recoginzed in the liver, kidney and spleen. The pathological findings appeared most remarkably in mice with m-nitroaniline, but were weakened in mice with alkyl ethers. Therefore it seemed that these toxic effects were weakened when OH and O.R group attached to para-position against nitro-group of m-nitroaniline.
  • 河守 和彦
    1954 年 50 巻 1 号 p. 17-26,en1
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Prof. Hara has previously suggested on the two distinguished divisions in the extrapyramidal system, namely the bulbocapnine-reacting system and the harmine-reacting system. In his idea some experiments were carried out in order to explain the significance of striatum for the development of action of extrapyramidal poisons. The corpus striatum of a mouse was divided into six portions by means of the high frequency electrocautery. In determining the effect of harmine and bulbocapnine under these conditions, it was proved that the action of harmine was remarkably decreased when the anterior portion of striatum was injured, and that the injury of the posterior portion exerted a great reduction of action of bulbocapnine.
  • 河守 和彦
    1954 年 50 巻 1 号 p. 27-37,en2
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Using mice as in the first report (see this Breviaria No. 4) hypothalamus and mid-brain were sectioned independently into four portions by the high frequency electrocautery, while the vermis of cerebellum was destroyed either on one or on both sides. The injury on hypothalamus and mid-brain, especially on the ventral portion of their both sides caused a noticeable inhibition against the action of extrapyramidal poisons, whereas the partial injury on midbrain or on cerebellum seemed, however, to have no direct effect on these poisons.
  • 大澤 京子
    1954 年 50 巻 1 号 p. 38-52,en2
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Studies were performed on chicken sarcoma of Chiba and Rous strains and undermentioned results wer obtained. (1) Blood picture and serum protein changed regularly according to the development of sarcoma. (2) Temporary interruption of blood circulation by blockade had no effect on chicken bearing sarcoma of both strains. (3) “Toxohormone” was extracted from sarcoma tissue of both strains and perfused fluid was collected through sarcoma tissues of both. strains. (4) Very similarly pharmacological actions were observed between toxohormone and perfusate. (5) The resistance against sarcoma was obtained in chicken by pretreatment of toxohormone. (6) The increasing of resistance by toxohormone pretreatment seems mainly due to the histogenous factor.
  • 飯田 正一
    1954 年 50 巻 1 号 p. 53-59,en2
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    The activity to oxidize ethyl alcohol was determined by using the blood of horses, cows and rabbits manometrically with Warburg's apparatus. The data indicated that the corpuscles of horses, cows and rabbits possess the capacity of oxidizing alcohol to a certain extent, while the sera were not capable of oxidizing alcohol. In the rabbits acquiring a tolerance for alcohol by repetitious injection overa period of about two months, the oxidizing activity of corpuscles increases twofold as compared with those of normal rabbits, while the serum remains incapable of oxidizing alcohol. The amount of alcohol oxidized in blood itself, therefore, is calculated at less than one per cent of the total amount of alcohol oxidized in the whole body of rabbit, even after habituation.
  • 松村 元始
    1954 年 50 巻 1 号 p. 60-65,en3
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Small doses of salicylamide produced transitorily flaccid paralysis and a decrease in muscle tone in mice and rabbits similar to those observed after myanesin. Its analgesic action was not so much potent compared. with acetylsalicylic acid or aminopyrin either by modified Heffner's method or by Hardy's radiant heat method. There appears to be a relation between the analgesic and antipyretic activities of salicylamide and the presence of its paralyzing action. When paralysis was not apparent the drug did not so markedly possess antipyretic effect in rabbits.
  • 竹内 道雄, 山岡 正幸, 黒河内 寛
    1954 年 50 巻 1 号 p. 66-69,en3
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    The groups of rats injected a convulsive dose Qf nicotine (5 mg/kg) once a day for 30 to 120 days were compared with those of untreated with examination on the following : (1) convulsion induced by nicotine, (2) effect of nicotine on the cellular respiration of cerebral cortex, liver and kidney, and (3) nicotine inactivation by liver. As the results it was proved that no significant difference between both groups of animals could be found.
  • 山本 巖, 竹内 道雄, 辻本 明
    1954 年 50 巻 1 号 p. 70-75,en3
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    A micromethod for determination of nicotine by BrCN reaction was devised in which the excretion and elimination of nicotine injected in rabbits was determined in urine.
  • 橋本 虎六, 森田 淑子, 松山 俊介
    1954 年 50 巻 1 号 p. 76-94,en3
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Tested compounds were camphor, trans π-, 10-, p-, o-oxocamphor, trans π-oxycamphor, isoketopinic acid and Coramine. Among them, merely 1x 10-4m trans n-oxocamphor transiently increased the cardiac efficiency by 20% (The O2-uptake of heart decreased by 20%, while the cardiac output and aortic pressure did not show any remarkable change.). The decreased O2-uptake and augmented aerobic lactic acid formation of rat's brain and cardiac muscle slices by 5x10-3m of it was observed, and it was proved that this phenomenon was the influence on Pasteur effect through the inhibitory effect on the dehydrogenase systems. 10-Oxocamphor also had similar effects on tissue respiration.
  • 淺山 秀夫
    1954 年 50 巻 1 号 p. 95-103,en4
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
    Dilatator sectors and sphincter rings of rabbit, cat and cow were suspended in oxygenated Ringer-solution and the effects of autonomic drugs on the tone of muscles were recorded. Result : 1) Parasympathicomimetics caused contraction of the sphincter except larger dose pilocarpine which caused relaxation. Their effects on the dilatator after larger doses involved occasional contraction which was abolished by atropine. 2) Sympathicomimetics caused relaxation of the sphincter and contraction of the dilatator. 3) Cholinesterase inhibitors caused contraction of the sphincter. 4) The effects of adrenolytics upon both muscles differed in varied drugs tested. 5) Synaptolytics like TEA and hexamethonium had no effect, while nicotine contracted the sphincter with small dose and relaxed with larger dose. 6) Parasympathicolytics relaxed the sphincter, but no effect on the dilatator. 7) The contraction of sphincter by acetylcholine were inhibited or abolished by DFP, nicotine, TEA, pilocarpine and parasympathicolytics. 8) The contraction of the dilatator by adrenaline was inhibited by adrenolytics. From those above results it is suggested that the innervation of sphincter is reciprocal, but that of dilatator is of an adrenergic nature
  • 1954 年 50 巻 1 号 p. a1-a21
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
  • 1954 年 50 巻 1 号 p. a22-a50
    発行日: 1954/11/20
    公開日: 2011/09/07
    ジャーナル フリー
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