Since Bayliss and Starling discovered secretin in 1902, humoral factors have been considered to play major role in the regulation of pancreatic secretion, but nervous factors have been supposed to play only a minor role.
There are few studies on the relationship between the central nervous system and pancreatic secretion, though many experimental and clinical experiences are encouraging to reevaluation nervous controls on pancreatic secretion.
Influence of the central nervous system on pancreatic secretion was studied on 36 cats in the present work. Experiments consisted of the following three parts. 1) Observation on pancreatic secretion by means of electrical stimulation to the anterior part of the hypothalamus and to the anterior cingulate, using the stereotaxic apparatus. 2) Observation of pancreatic secretion after administration of neostigmine. 3) Gross and histological studies on the pancreas and other organs by means of chronic electrical stimulation to the anterior part of the hypothalamus and administration of reserpine or acetylcholine.
Results obtained from these experiments are;
1) Each cat showed different level of basal pancreatic secretion, maintained by intravenous administration of 0.1unit/min secretin.
Neostigmine increased amylase activity but did not change the flow rate of pancreatic juice.
3) Slight decrease of the flow rate of the juice began one hour after the stimulation of the anterior part of the hypothalamus, and amylase concentration and output began slightly increase immediately after the stimulation to reach the maximum after four hours.
4) The flow rate of the juice slightly decreased till the third hour but increased through after the fouth hour of the stimulation of the anterior cingulate, while concentration and output of amylase decreased through after the stimulation.
5) As for chronic experiments using permanent implanted electrodes into the anterior part of the hypothalamus, neither gross nor histological changes in the pancreas were observed after the electric stimulation and after the simultaneous or alone administration of reserpine or acetylcholine.
6) Ulcers in the stomach or the duodenum were observed after the administration of reserpine or acetylcholine, but no ulcer was induced by the electric stimulation of the anterior part of the hypothalamus.
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