A case with squamous cell carcinoma of the pancreas is now reported. The case with squamous cell carcinoma is the first among 90 cases of pancreatic carcinoma in our departments. The carcinoma originated from ductal cell of the pancreas and occupied the head of the pancreas with the tumor size, 5×6 cm. There was infiltration of the cancer cell into the body of the pancreas. Metastasis to liver, lung, peritoneum, intestines, gall bladder, and various lymph nodes were evident. Residual pancreas was fibrotic with chronic pancreatitis secondary to the tumor. The result of pancreozymin-secretin (PS) test revealed normal water, bicarbonate and amylase output, but abnormally low output of trypsin and lipase. The dissociation of the digestive enzymes was also seen in the pancreatic tissue. The dissociation of the digestive enzymes indicates the importance of measuring trypsin and lipase in addition to amylase during PS-test.