Among 101 cases of chronic hepatitis, 41 were treated with corticosteroid and the rest served as control. All the patients were hospitalized between May 1961 and April 1965. The patients treated with corticosteroid received betamethazone from 2.0 to 4.0 mg as initial daily dosis and this was later reduced to maintenance dosis which was 1.0 to 1.5 mg daily. The average total dosis was 132.0 mg and duration of medication was 94.4 days. Hepatic function tests, such as SGOT, TGPT, TTT, ZST, and AP, were examined once in a week and protein fractionation was carried out once or twice in every month. From serial transaminase activity, these patients were divided into 5 patterns and effect or in fluence of corticosteroid on the hepatic function tests. 1) TTT, and ZST, were lower with corticosteroid administration, but after ceasing of it they started to rise again. 2) In protein fractions, the G-globulin was remarkedly reduced when dysproteinemia existed. 3) Generally SGPT level was higher than SGOT level in young adults and the reverse was observed in senile patients. 4) Rebound phenomena were frequently experinced in post transfusion viral hepatitis.
There have been many clinical reports regarding testing methods of digestion and absorption. However these methods have much difficulties in processing and take much time until result is obtained in addition to also giving trouble to patients. Therefore, we have devised a new simple method of testing protein digestion by having patients swallow small barium tablet which is coated with protein. The small tablet consists of barium and is coated with protein on its surface, being 6 mm. in diameter and 3mm. thick. After swallowed, the superficially coated protein of the tablet will be digested with intestinal enzymes and the barium tablet will be easily dissolved, changing the shape. The change in the shape of barium tablet infers destruction of surface of the tablet coated with protein and further digestion of the protein layer. These process can be easily observed through x-ray examination. By knowing number of tablets to be dissolved within a definite time, we can easily recognize the degree of the digestive power to protein and motility of a patient.
For the purpose to elucidate the relationship between bile ductule and liver cell in chronic hepatitis, cholangiolitic hepatitis, and liver cirrhosis was studied by histopathological and histochemical observations and also by the reconstruction model of thehuman liver biopsy specimens. The results of the study are briefly presented in the following. 1. It was elucidated that bile ductule cell contain a substance positive to PAS stain, and the enzymatic activity of the cells in the proxymal portion was more intense than those of the distal portion. The difference is due to the number of the mitochondria visualized with the Regand stain, and has a parallel relation to the destruction of liver parenchyma. In the threedimensional observation with reconstruction model of the liver, there is an ample reason to suppose polarization from theproliferated bile ductule cells into liver cell through the overall changes observable such as the communication of bile ductules with regenerated nodules. However, it has been impossible to determine the direction of the polarization. 2. In the sections of livers prepared with cryostat the activity of aminepeptidase is detected to a moderate degree in the cytoplasm of liver cells but the bile ductules show hardly any enzymic activity. 3. The proliferated bile ductules in cholangiolitic hepatitis presented somewhat different histological and histochemical properties from those observed in either chronic hepatitis and liver cirrhosis. 4. Cluster of cells with high enzymic activity were observed around the regnerated nodules in an array as if to encapsulate them, and it is assumed that this picture reflects the condensation of mitochondria due to the comprission of liver cells by regenerated nodules