A 77-years old man admitted to our hospital, complaining of abdominal distension and dull epigastric pain. Fluoloscopic and endoscopic examination of the stomach, he was diagnosed of cancer of the stomach.(Borrman III), Adenocarcinoma. He had been treated with only anticancer drugs, because of old age and his anxiety for the operation. However, he was getting worse gradually and suffered from a severe pain on the cervical region, a few days before his death. His post-mortem examination revealed gastric cancer metastase to the pancreas and parotitis. During his course, his serum amylase isozyme pattern changed to pancreatic dominant pattern from normal, then to carotic dominant pattern. This case suggests the possible organ relationship between the pancreas and the parotis from the view point of amylase isozyme.
Isoenzymes of alkaline phosphatase (ALP) are usually normal in the serum of acute viral hepatitis. We discovered a case of acute hepatitis who had an abnormal ALP isoenzyme in blood. This isoenzyme migrated more toward cathode than intestinal ALP by electrophoretic separation of isoenzymes. Enzymologic natures of this isoenzyme were similar to those of normal hepatic isoenzyme on inhibition by L-phenylalanine, L-homoarginine and L-leucine. This isoenzyme was detected in the liver extract also. Decrease in electrophoretic mobilities ofisoenzymes was seen both in hepatic and abnormal ALP by neuraminidase digestion, but retardation rate was more scarce in abnormal ALP. These data indicate that this isoenzyme is made by the liver which exhibits abnormal metabolism.