Although many studies on the genesis of the peptic ulcer have been reported, the precise process developing to the ulcer is not yet clarified completely.
In this study, the administration of"Cinchophen"to the dog was adopted for making the chronic ulcers, because of its validity of easy production of the ulcers which are macroscopically and microscopically similar to those of human.
The single course of administration of"Cinchophen"was given 48 dogs and other 14 dogs were observed serially on the developmental process of the ulcers using per-peritoneal gastroscope and GTF.
In the group of the single administration;
1) The ulcer could be recognized in 43 among 48 dogs (89.6%).
2) The single ulcer was found in 7 cases (16.3%) and the multiple ulcers were found in the other 36 cases (83.7%).
3) The ulcers located at the border section between the different glandular areas, ranged to the deep layers and were ranked as the grade of ul III or ul IV.
4) The form of the ulcers was almost round or oval.
5) Excepting at the above-mentioned border section, there were generally observed the shallow ulcers which were classified as ul II with their diameters less than 10mm in 80%.
In the group administered the repeated courses of"cinchophen"under the serial abservation by gastroscopy;
1) There appeared multiformed hemorrhagic erosions and shallow ulcers in all cases, with the total dosage of 2-10gm (6.4gm on the average) of"Cinchophen"during 3-8 days (5.3 days on the average).
2) Most of them were healed during the successive administration of"Cinchophen".
3) Erosions located at the border zone were apt to develop to ulcers.
4) Speaking of 12 dogs in which gastric ulcers were observed, average days requiring to develop to ulcers were 1.1 days (6-18 days) and the mean dosage was 14.1gm (7.5-21.0gm).
It was clarified, through this study, the multiple hemorrhagic erosions produced by"Cinchophen"were healed in most of cases, while those located at the border zone between the different glandular areas had a tendency to develop to ulcers reaching the deeper layers.
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