A 27-year old woman with SLE was admitted to the hospital because of diarrhea, abdominal pain and vomiting. The laboratory data reveald marked proteinuria, but wirum amylase and cholesterol were normal. She was diagnosed SLE in 1973 and she has taken predonisolone, 10-60mg/day. A month before admission, the patient was seen in the clinic and examination revealed complement decreasing, while she was taking predonisolone, 10mg/day. On the third hospital day, predonisolone was increased to 50mg/day because of considering exacerbation of SLE, so the next day, abdominal pain was diminished. On the 13th hospital day, hyperamylasemia and amylasuria were appeared, and on the amylase isozyme pattern, 85% of total serum amylase was pancreatic type. Asymptomatic hyperamylasemia continued 31 days. Her pancreozymin-secretin test and ERCP were normal. We examined 22 cases of SLE, we saw three similar cases (involving this case). (13.6%) We considered the cause of hyperamylasemia was by predonisolone, but the incidence of pancreatic type hyperamylasemia was independent on duration or dose of predonisolone.