The scintillation camera is employed for dynamic liver function studies with ¹³¹I labelled BSP. This technique provides a unique timed anatomic record of the rate and magnitude of excretion of labelled dye, and the study indicates it to be of significant value in the differentiation of jaundice.
The subjects comprised 66 cases of various liver diseases including 5 cases of acute hepatitis, 18 cases of chronic hepatitis, 20 of livercirrhosis, 2 of fatty liver, 4 of Dubin Johnson's syndrom, 2 of Gilbert's disease, 2 of complete obstructive jaundice, 2 of incomplete obstructive jaundice and 10 of normal subjects.
By assuming a three compartments model, kinetic analysis of ¹³¹I-BSP distributions in various organs were calculated based upon the disappearance curve of ¹³¹I-BSP radioactivity in the serum, time dependent curve of radioactivity over the liver and urinary excretion of ¹³¹I-BSP in attempts to clarify the kinetic distribution of ¹³¹I-BSP and the time dependent pool size of ¹³¹I-BSP in each compartment such as serum pool, liver pool and the other pool.
The time dependent curves of Q₁ (t) which represent the disappearance curve of ¹³¹I-BSP from the plasma being decreased more slowly in the early stage in chronic hepatitis, livercirrhosis and obstructive jaundice than in normal subjects. The time dependent size of ¹³¹I-BSP pool in the liver, rises more slowly in the cases of acute hepatitis, livercirrhosis and chronic hepatitis than those in normal subjects during initial 30min.
The time showing the maximum points of the time dependent curve of Q₂ (t) is prolonged in the cases of livercirrhosis and obstructive jaundice and also the valves of maximum points are decreased in liver diseases. These facts indicate that the ¹³¹I-BSP uptake into the liver is decreased in liver diseases. While the maximum point of time dependent curve of Q₂ (t) decrease more markedly in livercirrhosis and acute hepatitis.
The individual values for the fractional rate constant for distribution and metabolism of ¹³¹I-BSP are expressed as k₀₁, k₀₂, k₁₂, k₁₃, k₂₁, k₂₃, k₃₁, and k₁₃. In controls, the calculated rate constant of k₂₁, expressing the uptake from the plasma to liver, is (7.08±1.32)×10^-2min^-1, k₁₂ is (1.974±0.1301)×10^-2min^-1 and k₀₂, expressing the excretion from liver into bile duct, is (3.994±1.10)×10^-3min^-1. The cases of acute hepatitis, liver cirrhosis and obstructive jaundice showed a more remarkable decrease in the values of k₂₁ and k₀₂ than normal subjects.
In the cases of Dubin Johnson's Syndrom, remarkable decrease (P<0.01) in the values of k₀₂ and billiary excretion of ¹³¹I-BSP is showed, but the second rising curve in time dependent curve of ¹³¹I-BSP radioactivity in serum is not demonstrated.
If the ratio of blood ¹³¹IBSP value in 30min, divided by the value in 2min. after intravenous injection of ¹³¹I-BSP is calculated, the ratio appears to be of significant value in differentiation of the various type of liver diseases.

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各種肝疾患の免疫グロブリンの意義はなお充分に明らかにされているとはいえない. 今回我々は急性肝炎, 慢性肝炎, 肝硬変症, 及び脂肪肝, 閉塞性黄疸の免疫グロブリン値の検討及び慢性活動性肝炎のステロイド療法時における免疫グロブリンの動態を検討し次の結論を得た. 結論: 免疫グロブリンは各種肝疾患の診断, 病状及び予後判定に重要でなかでも IgG と IgM が重要であり, 慢性肝炎及び肝硬変症ではこれらを介して活動型, 非活動型が区別され得る可能性がある. 慢性活動性肝炎のステロイド療法時にも免疫グロブリン値の測定が有意義であると考える.

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家兎の膵管上皮には, これを被う alcian blue 陽性, alcian blue-P.A.S. で菫色に染まる被覆層があり, また, 同様の染色態度を示す胚細胞が上皮配列間に介在している.
家兎膵管内に低圧で, 小量の胆汁やトリプシンを注入しても, これらの膵管上皮被覆層や胚細胞には変化がみられず, 膵実質の変化もきわめて軽微であるが, これらに β-glucuronidase を併用すると激しい膵炎を発生する. 胆汁と β-glucuronidase の併用による膵炎は膵管上皮の破綻と関係があり, トリプシンと β-glucuronidaseの併用による膵炎では膵管の変化は軽度であるが, 膵は充血が強く, 実質障害も著しい. phospholipaseA を注入すると膵管上皮, 膵実質の両者に変化が認められる.

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日本人 (成人) に多い乳糖不耐症の原因を究明する目的で, (1) 牛乳摂取状況アンケート, (2) 種々の乳糖負荷試験, (3) 生検による小腸粘膜の光顕, 電顕的観察と disaccharidase 小腸活性測定, (4) 動物実験 (1) 生後における小腸 disaccharidase の消長, 2) 量別および年令別乳糖強化食飼育実験, 3) 乳糖分解酵素剤投与の小腸 lactase への影響) を行なつた. その結果, 成人の小腸 lactase 活性は正常健康者で欧米白人の約1/4と低く, 加令による低下もみられた. また, 動物実験で, 乳糖による小腸 lactase の基質誘導が年令と関係なく可能であることが証明された.
日本人の小腸 lactase 活性の低下は, 乳糖摂取の寡量に主因があると結論した.

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