Atopic dermatitis (AD) is a multifactorial, chronically-relapsing, eczematous disease that usually manifests hyperimmunoglobulinemia E and eosinophilia. The significance of this IgE and eosinophilia still remains unclear. The Th1/Th2 balance theory can roughly outline the pathomechanisms of AD; however, the details remain largely unknown. Therapeutic guidelines are based on avoidance of exacerbating factors, skin care, and topical/oral medication. The recent development of topical calcineurin inhibitors has had a highly beneficial impact on the treatment of AD in combination with topical steroids.